ID   HTF1_BLAOR              Reviewed;           8 AA.
AC   P84261; P04548;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   26-FEB-2020, entry version 33.
DE   RecName: Full=Hypertrehalosaemic factor 1;
DE   AltName: Full=Adipokinetic hormone 1;
DE            Short=BlaOr-AKH-1;
DE   AltName: Full=Hypertrehalosaemic factor I;
DE   AltName: Full=Hypertrehalosaemic neuropeptide I;
OS   Blatta orientalis (Oriental cockroach).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Blatta.
OX   NCBI_TaxID=6976;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=2340112; DOI=10.1515/bchm3.1990.371.1.345;
RA   Gaede G., Rinehart K.L. Jr.;
RT   "Primary structures of hypertrehalosaemic neuropeptides isolated from the
RT   corpora cardiaca of the cockroaches Leucophaea maderae, Gromphadorhina
RT   portentosa, Blattella germanica and Blatta orientalis and of the stick
RT   insect Extatosoma tiaratum assigned by tandem fast atom bombardment mass
RT   spectrometry.";
RL   Biol. Chem. Hoppe-Seyler 371:345-354(1990).
RN   [2]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT TRP-8.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=19257902; DOI=10.1186/1471-2148-9-50;
RA   Roth S., Fromm B., Gaede G., Predel R.;
RT   "A proteomic approach for studying insect phylogeny: CAPA peptides of
RT   ancient insect taxa (Dictyoptera, Blattoptera) as a test case.";
RL   BMC Evol. Biol. 9:50-50(2009).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC       {ECO:0000269|PubMed:2340112}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2340112}.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; S08995; S08995.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Hypertrehalosaemic factor 1"
FT                   /id="PRO_0000043427"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:19257902"
FT   MOD_RES         8
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:19257902"
SQ   SEQUENCE   8 AA;  991 MW;  86745775B9C452D6 CRC64;
     QVNFSPNW