ID   HTF1_ROMMI              Reviewed;          10 AA.
AC   P18110;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   11-DEC-2019, entry version 62.
DE   RecName: Full=RO-1;
DE   AltName: Full=Hypertrehalosaemic factor;
DE   AltName: Full=RO I;
OS   Romalea microptera (Eastern lubber grasshopper) (Romalea guttata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Romaleidae; Romaleinae; Romalea.
OX   NCBI_TaxID=7007;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   THR-10.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=3226948; DOI=10.1016/0196-9781(88)90107-6;
RA   Gaede G., Hilbich C., Beyreuther K., Rinehart K.L. Jr.;
RT   "Sequence analyses of two neuropeptides of the AKH/RPCH-family from the
RT   lubber grasshopper, Romalea microptera.";
RL   Peptides 9:681-688(1988).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Flight; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..10
FT                   /note="RO-1"
FT                   /id="PRO_0000043439"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3226948"
FT   MOD_RES         10
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000269|PubMed:3226948"
SQ   SEQUENCE   10 AA;  1163 MW;  056236745771A9C4 CRC64;
     QVNFTPNWGT