ID   HTF2_BLAOR              Reviewed;           8 AA.
AC   P84258; P04549;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   26-FEB-2020, entry version 33.
DE   RecName: Full=Hypertrehalosaemic factor 2;
DE   AltName: Full=Hypertrehalosaemic factor II;
DE   AltName: Full=Hypertrehalosaemic neuropeptide II;
OS   Blatta orientalis (Oriental cockroach).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Blatta.
OX   NCBI_TaxID=6976;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, PYROGLUTAMATE FORMATION AT GLN-1, AMIDATION AT
RP   TRP-8, AND SUBCELLULAR LOCATION.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=2340112; DOI=10.1515/bchm3.1990.371.1.345;
RA   Gaede G., Rinehart K.L. Jr.;
RT   "Primary structures of hypertrehalosaemic neuropeptides isolated from the
RT   corpora cardiaca of the cockroaches Leucophaea maderae, Gromphadorhina
RT   portentosa, Blattella germanica and Blatta orientalis and of the stick
RT   insect Extatosoma tiaratum assigned by tandem fast atom bombardment mass
RT   spectrometry.";
RL   Biol. Chem. Hoppe-Seyler 371:345-354(1990).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC       {ECO:0000269|PubMed:2340112}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2340112}.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; S08996; S08996.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Hypertrehalosaemic factor 2"
FT                   /id="PRO_0000043428"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2340112"
FT   MOD_RES         8
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:2340112"
SQ   SEQUENCE   8 AA;  1006 MW;  86745771A9D1A736 CRC64;
     QLTFTPNW