ID   HTF2_LEPDE              Reviewed;           8 AA.
AC   P84257; P04549;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   02-JUN-2021, entry version 32.
DE   RecName: Full=Hypertrehalosaemic factor 2;
DE   AltName: Full=Hypertrehalosaemic factor II;
DE   AltName: Full=LeD-CC-II;
OS   Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora
OS   decemlineata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Chrysomeloidea; Chrysomelidae; Chrysomelinae; Doryphorini; Leptinotarsa.
OX   NCBI_TaxID=7539;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, PYROGLUTAMATE FORMATION AT GLN-1, AMIDATION AT
RP   TRP-8, AND SUBCELLULAR LOCATION.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=2576128; DOI=10.1016/0196-9781(89)90023-5;
RA   Gaede G., Kellner R.;
RT   "The metabolic neuropeptides of the corpus cardiacum from the potato beetle
RT   and the American cockroach are identical.";
RL   Peptides 10:1287-1289(1989).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects). Involved in the control of
CC       amino acid metabolism during flight. {ECO:0000269|PubMed:2576128}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2576128}.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; B44960; B44960.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Hypertrehalosaemic factor 2"
FT                   /id="PRO_0000043434"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2576128"
FT   MOD_RES         8
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:2576128"
SQ   SEQUENCE   8 AA;  1006 MW;  86745771A9D1A736 CRC64;
     QLTFTPNW