ID   HTF2_PERAM              Reviewed;           8 AA.
AC   P84256; P04549;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   11-DEC-2019, entry version 37.
DE   RecName: Full=Hypertrehalosaemic factor 2;
DE   AltName: Full=Hypertrehalosaemic factor II;
DE   AltName: Full=Neuropeptide M-II;
DE   AltName: Full=PeA-CAH-II;
DE   AltName: Full=Periplanetin CC-2;
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT TRP-8.
RX   PubMed=6548628; DOI=10.1016/0006-291x(84)91560-2;
RA   Witten J.L., Schaffer M.H., O'Shea M., Cook J.C., Hemling M.E.,
RA   Rinehart K.L. Jr.;
RT   "Structures of two cockroach neuropeptides assigned by fast atom
RT   bombardment mass spectrometry.";
RL   Biochem. Biophys. Res. Commun. 124:350-358(1984).
RN   [2]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=6591205; DOI=10.1073/pnas.81.17.5575;
RA   Scarborough R.M., Jamieson G.C., Kalish F., Kramer S.J., McEnroe G.A.,
RA   Miller C.A., Schooley D.A.;
RT   "Isolation and primary structure of two peptides with cardioacceleratory
RT   and hyperglycemic activity from the corpora cardiaca of Periplaneta
RT   americana.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:5575-5579(1984).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC       {ECO:0000269|PubMed:6591205}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6591205}.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; B49823; B49823.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Hypertrehalosaemic factor 2"
FT                   /id="PRO_0000043438"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:6548628"
FT   MOD_RES         8
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:6591205"
SQ   SEQUENCE   8 AA;  1006 MW;  86745771A9D1A736 CRC64;
     QLTFTPNW