ID   HTF4_XENLA              Reviewed;         152 AA.
AC   Q91605;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Transcription factor XE1.1;
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head;
RX   PubMed=8522197; DOI=10.1016/0378-1119(95)00544-g;
RA   Shain D.H., Zuber M.X.;
RT   "Identification of non-tissue-specific helix-loop-helix genes in Xenopus
RT   laevis.";
RL   Gene 165:319-320(1995).
CC   -!- FUNCTION: Transcriptional regulator. Involved in the initiation of
CC       neuronal differentiation. Activates transcription by binding to the E
CC       box-containing promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; U25959; AAA92047.1; -; mRNA.
DR   AlphaFoldDB; Q91605; -.
DR   SMR; Q91605; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           <1..152
FT                   /note="Transcription factor XE1.1"
FT                   /id="PRO_0000127233"
FT   DOMAIN          47..100
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..125
FT                   /note="Class A specific domain"
FT   REGION          123..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   152 AA;  17456 MW;  35138AF36552600C CRC64;
     RDDFSSDDMK SDDESSQKEM KSSRGRTSSI NEDEDLNPEQ KVEREKERRM ANNARERLRV
     RDINEAFKEL GRMCQLHLKS EKPQTKLLIL HQAVAVILNL EQQVRERNLN PKAACLKRRE
     EEKVSAVSAE PPNTHPGVHP GLTDTTNPMG HM