ID   HTF_BLADI               Reviewed;          72 AA.
AC   Q17128;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Hypertrehalosaemic prohormone;
DE   Contains:
DE     RecName: Full=Hypertrehalosaemic hormone;
DE              Short=HTH;
DE     AltName: Full=Hypertrehalosaemic neuropeptide;
DE   Contains:
DE     RecName: Full=Hypertrehalosaemic hormone precursor-related peptide;
DE   Flags: Precursor;
OS   Blaberus discoidalis (Tropical cockroach).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC   Blaberinae; Blaberus.
OX   NCBI_TaxID=6981;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=9220026; DOI=10.1016/s0303-7207(97)00078-6;
RA   Lewis D.K., Jezierski M.K., Keeley L.L., Bradfield J.Y.;
RT   "Hypertrehalosemic hormone in a cockroach: molecular cloning and
RT   expression.";
RL   Mol. Cell. Endocrinol. 130:101-108(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 22-31, PYROGLUTAMATE FORMATION AT GLN-22, AND AMIDATION
RP   AT THR-31.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=3778476; DOI=10.1016/0006-291x(86)90784-9;
RA   Hayes T.K., Keeley L.L., Knight D.W.;
RT   "Insect hypertrehalosemic hormone: isolation and primary structure from
RT   Blaberus discoidalis cockroaches.";
RL   Biochem. Biophys. Res. Commun. 140:674-678(1986).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in corpora cardiaca.
CC       {ECO:0000269|PubMed:9220026}.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   EMBL; U35277; AAA79691.1; -; mRNA.
DR   AlphaFoldDB; Q17128; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:3778476"
FT   CHAIN           22..72
FT                   /note="Hypertrehalosaemic prohormone"
FT                   /id="PRO_0000000929"
FT   PEPTIDE         22..31
FT                   /note="Hypertrehalosaemic hormone"
FT                   /id="PRO_0000000930"
FT   PEPTIDE         35..72
FT                   /note="Hypertrehalosaemic hormone precursor-related
FT                   peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000000931"
FT   MOD_RES         22
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3778476"
FT   MOD_RES         31
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000269|PubMed:3778476"
SQ   SEQUENCE   72 AA;  7885 MW;  DA63C96EA35EBB11 CRC64;
     MNHLVKVLIV VVAIALVLCE AQVNFSPGWG TGKRSAVQDS PCKGSAESLM YIYKLVQNEA
     QKILECEKFS SN