ID   HTF_HELZE               Reviewed;          10 AA.
AC   P16353;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 3.
DT   02-JUN-2021, entry version 63.
DE   RecName: Full=Hypertrehalosaemic hormone;
DE   AltName: Full=HeZ-HRTH;
OS   Helicoverpa zea (Corn earworm moth) (Heliothis zea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Heliothinae; Helicoverpa.
OX   NCBI_TaxID=7113;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   ASN-10.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=3415690; DOI=10.1016/s0006-291x(88)81091-x;
RA   Jaffe H., Raina A.K., Riley C.T., Fraser B.A., Bird T.G., Tseng C.M.,
RA   Zhang Y.S., Hayes D.K.;
RT   "Isolation and primary structure of a neuropeptide hormone from Heliothis
RT   zea with hypertrehalosemic and adipokinetic activities.";
RL   Biochem. Biophys. Res. Commun. 155:344-350(1988).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; A31571; A31571.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Hypertrehalosaemic hormone"
FT                   /id="PRO_0000043432"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3415690"
FT   MOD_RES         10
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:3415690"
SQ   SEQUENCE   10 AA;  1096 MW;  8E70367865A5B9D1 CRC64;
     QLTFSSGWGN