ID   HTF_LOCMI               Reviewed;          10 AA.
AC   P81626;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   11-DEC-2019, entry version 50.
DE   RecName: Full=Hypertrehalosaemic hormone;
DE            Short=Lom-HrTH;
DE   AltName: Full=Hypertrehalosaemic neuropeptide;
DE   AltName: Full=Peptide hormone;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, TISSUE SPECIFICITY,
RP   PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT PRO-10.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=10214953; DOI=10.1016/s0014-5793(99)00299-9;
RA   Siegert K.J.;
RT   "Locust corpora cardiaca contain an inactive adipokinetic hormone.";
RL   FEBS Lett. 447:237-240(1999).
CC   -!- FUNCTION: The in vivo function of this peptide is unknown. Has no
CC       adipokinetic or hypertrehalosaemic activity in locusts. Has
CC       hypertrehalosaemic activity in the cockcroach P.americana.
CC       {ECO:0000269|PubMed:10214953}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized in the neurosecretory cells of the
CC       brain, and transported to the storage lobe of the corpora cardiaca.
CC       {ECO:0000269|PubMed:10214953}.
CC   -!- MASS SPECTROMETRY: Mass=1204.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10214953};
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Hypertrehalosaemic hormone"
FT                   /id="PRO_0000043445"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:10214953"
FT   MOD_RES         10
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:10214953"
SQ   SEQUENCE   10 AA;  1222 MW;  81BFF67AB415B9D1 CRC64;
     QVTFSRDWSP