ID   HTF_NAUCI               Reviewed;          10 AA.
AC   P84218; P10939;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   11-DEC-2019, entry version 34.
DE   RecName: Full=Hypertrehalosaemic hormone;
DE            Short=HTH;
DE   AltName: Full=Hypertrehalosaemic neuropeptide;
OS   Nauphoeta cinerea (Cinereous cockroach) (Gray cockroach).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC   Oxyhaloinae; Nauphoeta.
OX   NCBI_TaxID=6990;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   THR-10.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=3801028; DOI=10.1016/s0006-291x(86)80240-6;
RA   Gaede G., Rinehart K.L. Jr.;
RT   "Amino acid sequence of a hypertrehalosaemic neuropeptide from the corpus
RT   cardiacum of the cockroach, Nauphoeta cinerea.";
RL   Biochem. Biophys. Res. Commun. 141:774-781(1986).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; A26381; A26381.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Hypertrehalosaemic hormone"
FT                   /id="PRO_0000043436"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3801028"
FT   MOD_RES         10
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000269|PubMed:3801028"
SQ   SEQUENCE   10 AA;  1092 MW;  056236786775B9C4 CRC64;
     QVNFSPGWGT