ID   HTF_TABAT               Reviewed;          10 AA.
AC   P14596;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   02-JUN-2021, entry version 63.
DE   RecName: Full=Hypertrehalosaemic factor;
DE   AltName: Full=Dipteran corpora cardiaca factor II;
DE            Short=DCC II;
DE   AltName: Full=HOTH;
OS   Tabanus atratus (Black horse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=7207;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   TYR-10.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=2813385; DOI=10.1073/pnas.86.20.8161;
RA   Jaffe H., Raina A.K., Riley C.T., Fraser B.A., Nachman R.J., Vogel V.W.,
RA   Zhang Y.-S., Hayes D.K.;
RT   "Primary structure of two neuropeptide hormones with adipokinetic and
RT   hypotrehalosemic activity isolated from the corpora cardiaca of horse flies
RT   (Diptera).";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:8161-8164(1989).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; B33995; B33995.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Hypertrehalosaemic factor"
FT                   /id="PRO_0000043440"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2813385"
FT   MOD_RES         10
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000269|PubMed:2813385"
SQ   SEQUENCE   10 AA;  1169 MW;  916036786771A9D1 CRC64;
     QLTFTPGWGY