ID   HTF_TENMO               Reviewed;           8 AA.
AC   P67789; P25419;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   02-JUN-2021, entry version 31.
DE   RecName: Full=Hypertrehalosaemic factor;
DE   AltName: Full=HOTH;
DE   AltName: Full=Hypertrehalosaemic neuropeptide;
OS   Tenebrio molitor (Yellow mealworm beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrio.
OX   NCBI_TaxID=7067;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT TRP-8.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=2381871; DOI=10.1016/0196-9781(90)90042-4;
RA   Gaede G., Rosinski G.;
RT   "The primary structure of the hypertrehalosemic neuropeptide from
RT   tenebrionid beetles: a novel member of the AKH/RPCH family.";
RL   Peptides 11:455-459(1990).
CC   -!- FUNCTION: Hypertrehalosaemic factors are neuropeptides that elevate the
CC       level of trehalose in the hemolymph (trehalose is the major
CC       carbohydrate in the hemolymph of insects).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; A43976; A43976.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Hypertrehalosaemic factor"
FT                   /id="PRO_0000043441"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2381871"
FT   MOD_RES         8
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:2381871"
SQ   SEQUENCE   8 AA;  1005 MW;  86745775B9C44736 CRC64;
     QLNFSPNW