ID   HTHR_MYCBO              Reviewed;         188 AA.
AC   P67443; A0A1R3Y437; Q50720; X2BNW8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=HTH-type transcriptional regulator Mb3439c {ECO:0000305};
GN   OrderedLocusNames=BQ2027_MB3439C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Negatively regulates the expression of sulfate ester
CC       dioxygenase Mb3440 and its own expression.
CC       {ECO:0000250|UniProtKB:P9WMC3}.
CC   -!- INDUCTION: Negatively autoregulated. {ECO:0000250|UniProtKB:P9WMC3}.
CC   -!- DOMAIN: Contains an N-terminal DNA-binding domain and a C-terminal
CC       ligand binding pocket. {ECO:0000250|UniProtKB:P9WMC3}.
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DR   EMBL; LT708304; SIU02067.1; -; Genomic_DNA.
DR   RefSeq; NP_857079.1; NC_002945.3.
DR   RefSeq; WP_003417984.1; NC_002945.4.
DR   AlphaFoldDB; P67443; -.
DR   SMR; P67443; -.
DR   EnsemblBacteria; SIU02067; SIU02067; BQ2027_MB3439C.
DR   GeneID; 45427401; -.
DR   PATRIC; fig|233413.5.peg.3774; -.
DR   OMA; MRVWART; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..188
FT                   /note="HTH-type transcriptional regulator Mb3439c"
FT                   /id="PRO_0000070671"
FT   DOMAIN          17..77
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        40..59
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   188 AA;  20609 MW;  7B226876C5A43630 CRC64;
     MTTRPATDRR KMPTGREEVA AAILQAATDL FAERGPAATS IRDIAARSKV NHGLVFRHFG
     TKDQLVGAVL DHLGTKLTRL LHSEAPADII ERALDRHGRV LARALLDGYP VGQLQQRFPN
     VAELLDAVRP RYDSDLGARL AVAHALALQF GWRLFAPMLR SATGIDELTG DELRLSVNDA
     VARILEPH