ID   HTHR_MYCTO              Reviewed;         188 AA.
AC   P9WMC2; L0TE16; P67442; Q50720;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=HTH-type transcriptional regulator MT3513 {ECO:0000305};
GN   OrderedLocusNames=MT3513;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Negatively regulates the expression of sulfate ester
CC       dioxygenase MT3514 and its own expression.
CC       {ECO:0000250|UniProtKB:P9WMC3}.
CC   -!- INDUCTION: Negatively autoregulated. {ECO:0000250|UniProtKB:P9WMC3}.
CC   -!- DOMAIN: Contains an N-terminal DNA-binding domain and a C-terminal
CC       ligand binding pocket. {ECO:0000250|UniProtKB:P9WMC3}.
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DR   EMBL; AE000516; AAK47851.1; -; Genomic_DNA.
DR   PIR; B70736; B70736.
DR   RefSeq; WP_003417984.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMC2; -.
DR   SMR; P9WMC2; -.
DR   EnsemblBacteria; AAK47851; AAK47851; MT3513.
DR   GeneID; 45427401; -.
DR   KEGG; mtc:MT3513; -.
DR   PATRIC; fig|83331.31.peg.3771; -.
DR   HOGENOM; CLU_088572_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..188
FT                   /note="HTH-type transcriptional regulator MT3513"
FT                   /id="PRO_0000427329"
FT   DOMAIN          17..77
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        40..59
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   188 AA;  20609 MW;  7B226876C5A43630 CRC64;
     MTTRPATDRR KMPTGREEVA AAILQAATDL FAERGPAATS IRDIAARSKV NHGLVFRHFG
     TKDQLVGAVL DHLGTKLTRL LHSEAPADII ERALDRHGRV LARALLDGYP VGQLQQRFPN
     VAELLDAVRP RYDSDLGARL AVAHALALQF GWRLFAPMLR SATGIDELTG DELRLSVNDA
     VARILEPH