ID   HTMR_MYCBO              Reviewed;         139 AA.
AC   P67748; A0A1R3Y2G9; Q10810; X2BM43;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=HTH-type transcriptional repressor Mb2911 {ECO:0000250|UniProtKB:P9WME9};
GN   OrderedLocusNames=BQ2027_MB2911;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Represses expression of the HQNO methyltransferase htm gene
CC       by binding to its promoter region. {ECO:0000250|UniProtKB:P9WME9}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P9WME9}.
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DR   EMBL; LT708304; SIU01532.1; -; Genomic_DNA.
DR   RefSeq; NP_856556.1; NC_002945.3.
DR   RefSeq; WP_003899525.1; NC_002945.4.
DR   AlphaFoldDB; P67748; -.
DR   SMR; P67748; -.
DR   EnsemblBacteria; SIU01532; SIU01532; BQ2027_MB2911.
DR   GeneID; 45426875; -.
DR   PATRIC; fig|233413.5.peg.3195; -.
DR   OMA; EFVCLRI; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..139
FT                   /note="HTH-type transcriptional repressor Mb2911"
FT                   /id="PRO_0000054411"
FT   DOMAIN          6..138
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   139 AA;  14690 MW;  EB775A4CC03A24C0 CRC64;
     MGLADDAPLG YLLYRVGAVL RPEVSAALSP LGLTLPEFVC LRMLSQSPGL SSAELARHAS
     VTPQAMNTVL RKLEDAGAVA RPASVSSGRS LPATLTARGR ALAKRAEAVV RAADARVLAR
     LTAPQQREFK RMLEKLGSD