ID   HTMR_MYCTO              Reviewed;         139 AA.
AC   P9WME8; L0TCJ1; P67747; Q10810;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=HTH-type transcriptional repressor MT2955 {ECO:0000250|UniProtKB:P9WME9};
GN   OrderedLocusNames=MT2955;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Represses expression of the HQNO methyltransferase htm gene
CC       by binding to its promoter region. {ECO:0000250|UniProtKB:P9WME9}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P9WME9}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK47280.1; -; Genomic_DNA.
DR   PIR; B70925; B70925.
DR   RefSeq; WP_003899525.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WME8; -.
DR   SMR; P9WME8; -.
DR   EnsemblBacteria; AAK47280; AAK47280; MT2955.
DR   GeneID; 45426875; -.
DR   KEGG; mtc:MT2955; -.
DR   PATRIC; fig|83331.31.peg.3192; -.
DR   HOGENOM; CLU_083287_4_4_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..139
FT                   /note="HTH-type transcriptional repressor MT2955"
FT                   /id="PRO_0000427316"
FT   DOMAIN          6..138
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   139 AA;  14690 MW;  EB775A4CC03A24C0 CRC64;
     MGLADDAPLG YLLYRVGAVL RPEVSAALSP LGLTLPEFVC LRMLSQSPGL SSAELARHAS
     VTPQAMNTVL RKLEDAGAVA RPASVSSGRS LPATLTARGR ALAKRAEAVV RAADARVLAR
     LTAPQQREFK RMLEKLGSD