ID   HTOA_HAEIN              Reviewed;         466 AA.
AC   P45129;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Probable periplasmic serine protease do/HhoA-like;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   OrderedLocusNames=HI_1259;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22906.1; -; Genomic_DNA.
DR   PIR; A64113; A64113.
DR   RefSeq; NP_439414.1; NC_000907.1.
DR   RefSeq; WP_005694316.1; NC_000907.1.
DR   AlphaFoldDB; P45129; -.
DR   SMR; P45129; -.
DR   STRING; 71421.HI_1259; -.
DR   EnsemblBacteria; AAC22906; AAC22906; HI_1259.
DR   KEGG; hin:HI_1259; -.
DR   PATRIC; fig|71421.8.peg.1311; -.
DR   eggNOG; COG0265; Bacteria.
DR   HOGENOM; CLU_020120_1_1_6; -.
DR   OMA; IIGINRQ; -.
DR   PhylomeDB; P45129; -.
DR   BioCyc; HINF71421:G1GJ1-1287-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011782; Pept_S1C_Do.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF00595; PDZ; 2.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   TIGRFAMs; TIGR02037; degP_htrA_DO; 1.
DR   PROSITE; PS50106; PDZ; 2.
PE   3: Inferred from homology;
KW   Hydrolase; Periplasm; Protease; Reference proteome; Repeat;
KW   Serine protease; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..466
FT                   /note="Probable periplasmic serine protease do/HhoA-like"
FT                   /id="PRO_0000026936"
FT   DOMAIN          270..361
FT                   /note="PDZ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          367..458
FT                   /note="PDZ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   ACT_SITE        120
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        150
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        226
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   466 AA;  49434 MW;  ED050A00047B5851 CRC64;
     MKKTRFVLNS IALGLSVLST SFVAHVAQAT LPSFVSEQNS LAPMLEKVQP AVVTLSVEGK
     AKVDSRSPFL DDIPEEFKFF FGDRFAEQFG GRGESKRNFR GLGSGVIINA SKGYVLTNNH
     VIDGADKITV QLQDGREFKA KLVGKDEQSD IALVQLEKPS NLTEIKFADS DKLRVGDFTV
     AIGNPFGLGQ TVTSGIVSAL GRSTGSDSGT YENYIQTDAA VNRGNSGGAL VNLNGELIGI
     NTAIISPSGG NAGIAFAIPS NQASNLVQQI LEFGQVRRGL LGIKGGELNA DLAKAFNVSA
     QQGAFVSEVL PKSAAEKAGL KAGDIITAMN GQKISSFAEI RAKIATTGAG KEISLTYLRD
     GKSHDVKMKL QADDSSQLSS KTELPALDGA TLKDYDAKGV KGIEITKIQP NSLAAQRGLK
     SGDIIIGINR QMIENIRELN KVLETEPSAV ALNILRGDSN FYLLVQ