ID   HTPG_DESVH              Reviewed;         637 AA.
AC   Q728G0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Chaperone protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=Heat shock protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=High temperature protein G {ECO:0000255|HAMAP-Rule:MF_00505};
GN   Name=htpG {ECO:0000255|HAMAP-Rule:MF_00505}; OrderedLocusNames=DVU_2643;
OS   Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS   B-1760 / Hildenborough).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough;
RX   PubMed=15077118; DOI=10.1038/nbt959;
RA   Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA   Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA   Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA   Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G.,
RA   Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V.,
RA   Wall J.D., Voordouw G., Fraser C.M.;
RT   "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT   Desulfovibrio vulgaris Hildenborough.";
RL   Nat. Biotechnol. 22:554-559(2004).
CC   -!- FUNCTION: Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00505}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- INTERACTION:
CC       Q728G0; Q728L5: DVU_2588; NbExp=2; IntAct=EBI-10066697, EBI-10066767;
CC       Q728G0; Q72BU5: glpX; NbExp=4; IntAct=EBI-10066697, EBI-10066693;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00505}.
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DR   EMBL; AE017285; AAS97115.1; -; Genomic_DNA.
DR   RefSeq; WP_010939912.1; NC_002937.3.
DR   RefSeq; YP_011855.1; NC_002937.3.
DR   AlphaFoldDB; Q728G0; -.
DR   SMR; Q728G0; -.
DR   IntAct; Q728G0; 4.
DR   STRING; 882.DVU_2643; -.
DR   PaxDb; Q728G0; -.
DR   PRIDE; Q728G0; -.
DR   EnsemblBacteria; AAS97115; AAS97115; DVU_2643.
DR   KEGG; dvu:DVU_2643; -.
DR   PATRIC; fig|882.5.peg.2393; -.
DR   eggNOG; COG0326; Bacteria.
DR   HOGENOM; CLU_006684_3_0_7; -.
DR   OMA; MRRMKEM; -.
DR   PhylomeDB; Q728G0; -.
DR   Proteomes; UP000002194; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.790; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR019805; Heat_shock_protein_90_CS.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00298; HSP90; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome;
KW   Stress response.
FT   CHAIN           1..637
FT                   /note="Chaperone protein HtpG"
FT                   /id="PRO_0000236992"
FT   REGION          1..330
FT                   /note="A; substrate-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          331..551
FT                   /note="B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          552..637
FT                   /note="C"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
SQ   SEQUENCE   637 AA;  71660 MW;  71DEA234138A36B8 CRC64;
     MATAPASHAF RTEVRKMLHI ITHSLYTNRE IFLRELVSNA SDALDKLRFI RSRGDAVVAP
     DLAPGIDISV DKEARILTIA DTGVGMTRQE LMDNLGTIAR SGSEQFVADL AAAENAKDAD
     AASIIGRFGV GFYAVFMVAD RVEVTSRSYI EGEAAHTWTS DGLGEFTVEE ATGDIPQRGT
     VIKAHLREDA AEFLEKYRIE GILRKHSQFI SFPIRVDGEQ VNTTPALWRE PKFSITDEQY
     ADFYKHLTFD TEAPLRTLHV SVDAPVQFTG LVFVPPHGQE VFSMGRDRWG LDLYVRRVLI
     QRENKDLLPE YLGFLKGIVD TEDLPLNISR ETLQENVVVR KIGQTLTKQV LADLARLAAD
     DAEAYATFWR QHGKVFKLGY SDYANREKFA PLLRFNSSHH DDAQGLTSLD DYISRAREGQ
     KEIWYIAAPG REAARLDPRV EVFRRKGLEV LYLLEPIDEF VLETLDSYSD FSFKAVEHAD
     GEKLAQFEDT GPARDVTPLT EDEDAAFARL IERMKALLGD AVEDVRISHR LADSPACLVQ
     PGGASTSSMD RLLRVLHKDE SVPRKVFEVN RDHPILRNLL KVFTSDASDP LVEDTTRQLF
     ATSLMLDGYL KDPHELAAMM HRLMEKSGDW YKAVRGL