ID   HTPG_EHRRW              Reviewed;         637 AA.
AC   Q5HBT2; Q5FE32;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Chaperone protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=Heat shock protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=High temperature protein G {ECO:0000255|HAMAP-Rule:MF_00505};
GN   Name=htpG {ECO:0000255|HAMAP-Rule:MF_00505};
GN   OrderedLocusNames=Erum2450, ERWE_CDS_02490;
OS   Ehrlichia ruminantium (strain Welgevonden).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=254945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=15637156; DOI=10.1073/pnas.0406633102;
RA   Collins N.E., Liebenberg J., de Villiers E.P., Brayton K.A., Louw E.,
RA   Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M.,
RA   Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C.,
RA   Berthier D., Botha M., Joubert F., Corton C.H., Thomson N.R., Allsopp M.T.,
RA   Allsopp B.A.;
RT   "The genome of the heartwater agent Ehrlichia ruminantium contains multiple
RT   tandem repeats of actively variable copy number.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:838-843(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Welgevonden;
RX   PubMed=16547041; DOI=10.1128/jb.188.7.2533-2542.2006;
RA   Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA   Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.;
RT   "Comparative genomic analysis of three strains of Ehrlichia ruminantium
RT   reveals an active process of genome size plasticity.";
RL   J. Bacteriol. 188:2533-2542(2006).
CC   -!- FUNCTION: Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00505}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00505}.
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DR   EMBL; CR767821; CAH57962.1; -; Genomic_DNA.
DR   EMBL; CR925678; CAI26743.1; -; Genomic_DNA.
DR   RefSeq; WP_011154929.1; NC_006832.1.
DR   AlphaFoldDB; Q5HBT2; -.
DR   SMR; Q5HBT2; -.
DR   STRING; 254945.Erum2450; -.
DR   EnsemblBacteria; CAI26743; CAI26743; ERWE_CDS_02490.
DR   KEGG; eru:Erum2450; -.
DR   KEGG; erw:ERWE_CDS_02490; -.
DR   eggNOG; COG0326; Bacteria.
DR   HOGENOM; CLU_006684_3_0_5; -.
DR   OMA; MRRMKEM; -.
DR   BioCyc; ERUM254945:ERUM_RS01345-MON; -.
DR   Proteomes; UP000001021; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.790; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR019805; Heat_shock_protein_90_CS.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00298; HSP90; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Stress response.
FT   CHAIN           1..637
FT                   /note="Chaperone protein HtpG"
FT                   /id="PRO_0000224206"
FT   REGION          1..335
FT                   /note="A; substrate-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          336..559
FT                   /note="B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          560..637
FT                   /note="C"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
SQ   SEQUENCE   637 AA;  72536 MW;  30B5F10385A4B486 CRC64;
     MQGTVNSERL KFDAEVGKVL KLVIHSLYTN KDIFLRELIS NASDACDKLR YQSLSNQDLM
     DAGSELKIVI SVDKDKNRLY ISDNGIGMNR EDLINNLGTI AHSGTQKFLD AINSGASSQQ
     GVVELIGKFG VGFYSAFMVA SEVIVESCKA GESVGYQWKS SGDGEFVISQ LESDQVSRGT
     RITLALKPEE CEFVDKFRIE HIVTTYSYHI NYPVYFLNDK GEEERLNSEA AIWTKAKDEI
     SAEEHQNFFR TVAHVGGEPW MILHNKNEGV IEYTNLLYIP SIKPFDLFHP DRKCSVKLYV
     NKVFITEDNV QIIPQYLRFL KGIIDSSDLP LNISRETLQN NKIIEKIKRS LVKRVLSELK
     KKAESNIEDY TKFWDNFGSV LKEGLCESMN TEFREELISV CRFYSTHSND SLISLEDYIE
     RMKPEQNNIY YLTGNDLDSI KKSPQLEGFV SRGIEVLLLV DPVDDFWTNV VTDYQKVPLR
     SVIRADEDLE KFSDVEKDDE SKESQNEDAQ SKEKVDKFIS YAAQVLTNLV SNVRVSKKLT
     DSPVCLAVAD GSMDIRMERF LREQKQLNYK STKILEINSK HPIVSKMIDQ YAENGENAVL
     CNMLHLLLGQ ACILEGEELQ NVSDFAERMN NVLSQIN