ID   HTPG_FUSNN              Reviewed;         607 AA.
AC   Q8RGH4;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Chaperone protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=Heat shock protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=High temperature protein G {ECO:0000255|HAMAP-Rule:MF_00505};
GN   Name=htpG {ECO:0000255|HAMAP-Rule:MF_00505}; OrderedLocusNames=FN0321;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- FUNCTION: Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00505}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00505}.
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DR   EMBL; AE009951; AAL94527.1; -; Genomic_DNA.
DR   RefSeq; NP_603228.1; NC_003454.1.
DR   AlphaFoldDB; Q8RGH4; -.
DR   SMR; Q8RGH4; -.
DR   STRING; 190304.FN0321; -.
DR   EnsemblBacteria; AAL94527; AAL94527; FN0321.
DR   KEGG; fnu:FN0321; -.
DR   PATRIC; fig|190304.8.peg.901; -.
DR   eggNOG; COG0326; Bacteria.
DR   HOGENOM; CLU_006684_3_0_0; -.
DR   InParanoid; Q8RGH4; -.
DR   OMA; MRRMKEM; -.
DR   BioCyc; FNUC190304:G1FZS-918-MON; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IBA:GO_Central.
DR   Gene3D; 1.20.120.790; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR019805; Heat_shock_protein_90_CS.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00298; HSP90; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome;
KW   Stress response.
FT   CHAIN           1..607
FT                   /note="Chaperone protein HtpG"
FT                   /id="PRO_0000062988"
FT   REGION          1..323
FT                   /note="A; substrate-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          324..534
FT                   /note="B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          535..607
FT                   /note="C"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
SQ   SEQUENCE   607 AA;  70368 MW;  D1519D82B0FD1B08 CRC64;
     MKKEEKIFKA ETKELLNLMI HSIYTNKEIF LRELISNAND AIDKLKFQSL TDTDILKDND
     KFRIDISVDK DNRTLTISDN GIGMTYEEVD DNIGTIAKSG SKLFKEQLEE AKKGDIDIIG
     QFGVGFYSGF IVADKITLET KSPYSENGVK WISSGDGNYE IEEIAKQDRG TKITLHLKDG
     DEYNEFLEDW KIKDLVKKYS NYIRYEIYFG DEVINSTKPI WKKDKKELKD DDYNEFYKAT
     FHDWNDPLLH INLKVQGNIE YNALLFIPKK LPFDYYTKNF KRGLQLYTKN VFIMEKCEDL
     IPEYFNFISG LVDCDSLSLN ISREILQQNA ELQVISKNLE KKITSELEKI LKNDREKYVE
     FWKEFGRSIK AGVQDMFGMN KEKLQDLLIF VSSHDDKYTT LKEYVDRMGD NKEILYVPAE
     SVDAAKYLPK MEKLKEQGRE VLILTDKIDE FTLMAMRDYS GKEFKSINSS DFKFSDDKEK
     EEEVKKIADE NKELIEKAKE FLKDKVSEVE LSNNIGNSAS SLLAKGGLSL EMEKTLSEMT
     NNNDMPKAEK VLAINPEHVL FNRLKSSVNT EDFNKLVDVL YNQALLLEGF NIENPAEFIK
     NLNSLIK