ID   HTPG_GEOSL              Reviewed;         650 AA.
AC   P61185;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Chaperone protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=Heat shock protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=High temperature protein G {ECO:0000255|HAMAP-Rule:MF_00505};
GN   Name=htpG {ECO:0000255|HAMAP-Rule:MF_00505}; OrderedLocusNames=GSU2390;
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA;
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn M.L., Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J.,
RA   Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A.,
RA   Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E.,
RA   Lovley D.R., Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- FUNCTION: Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00505}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00505}.
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DR   EMBL; AE017180; AAR35763.1; -; Genomic_DNA.
DR   RefSeq; NP_953436.1; NC_002939.5.
DR   RefSeq; WP_010943026.1; NC_002939.5.
DR   AlphaFoldDB; P61185; -.
DR   SMR; P61185; -.
DR   STRING; 243231.GSU2390; -.
DR   PRIDE; P61185; -.
DR   EnsemblBacteria; AAR35763; AAR35763; GSU2390.
DR   KEGG; gsu:GSU2390; -.
DR   PATRIC; fig|243231.5.peg.2418; -.
DR   eggNOG; COG0326; Bacteria.
DR   HOGENOM; CLU_006684_3_0_7; -.
DR   InParanoid; P61185; -.
DR   OMA; MRRMKEM; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IBA:GO_Central.
DR   Gene3D; 1.20.120.790; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR019805; Heat_shock_protein_90_CS.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00298; HSP90; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome;
KW   Stress response.
FT   CHAIN           1..650
FT                   /note="Chaperone protein HtpG"
FT                   /id="PRO_0000062989"
FT   REGION          1..349
FT                   /note="A; substrate-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          350..566
FT                   /note="B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          567..650
FT                   /note="C"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
SQ   SEQUENCE   650 AA;  73731 MW;  26F8B8EE936972B4 CRC64;
     MSKTVKKFET EVQQLLDLVI HSLYSNKDIF LRELISNASD AIDKVLFESH QNAAVIEGEP
     EGKIKLIPDK DAGTLTIRDN GVGMTLEEVE KNIGTIAHSG TKAFLANLKE QNVADHPELI
     GQFGVGFYAS FMVADRVTLV TRRAGHDKAA GVRWESTGDG TYTVEECAKE TRGTEITLHL
     KEEMKEYLDE WKIRSIVRKY SDYVQYPIVM DVTRTEVPKG VNGEEIEGAG TIEKTEEETL
     NSMKAIWTRS KSEVTEEEYE EFYKHVSHDF EKPLKTIHYS AEGTSEFKAL LYLPAHKPFD
     LFMPERKKGV QLYVRRVFIT DSCEQLLPDY LRFVKGVVDS SDLPLNVSRE ILQEDVQIKR
     IQKSLVSKIL STLSEMREKE ADSYLDFYKE FGPVLKEGVH FDYANRDKLQ DLLLFESTAT
     DAGSFVSLKE YVERMPEGQE EIYFITGTSR AALEQSPHLE IFRKKGYEVL FLTDPVDEWV
     VQGLPEYGGK KLKAVDRGDV IPATEEEKKE QEAKREEAAK QYGDLLSFVK EKLAERVKEV
     RLSNRLTDSA CCLVADEHGL NANMERILRA MNQTVPESKR ILELNPDHPI MQVMATLFGK
     DKTNPRLADY CDLLYDQALL TEGSPIADPL RFTRLVAELM VADGKAAAGE