ID   HTPG_METC4              Reviewed;         626 AA.
AC   B7KPG0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Chaperone protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=Heat shock protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=High temperature protein G {ECO:0000255|HAMAP-Rule:MF_00505};
GN   Name=htpG {ECO:0000255|HAMAP-Rule:MF_00505}; OrderedLocusNames=Mchl_1155;
OS   Methylorubrum extorquens (strain CM4 / NCIMB 13688) (Methylobacterium
OS   extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=440085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM4 / NCIMB 13688;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Marx C., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium chloromethanicum
RT   CM4.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00505}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00505}.
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DR   EMBL; CP001298; ACK82043.1; -; Genomic_DNA.
DR   RefSeq; WP_012606035.1; NC_011757.1.
DR   AlphaFoldDB; B7KPG0; -.
DR   SMR; B7KPG0; -.
DR   EnsemblBacteria; ACK82043; ACK82043; Mchl_1155.
DR   KEGG; mch:Mchl_1155; -.
DR   HOGENOM; CLU_006684_3_0_5; -.
DR   OMA; MRRMKEM; -.
DR   BioCyc; MEXT440085:MCHL_RS05535-MON; -.
DR   Proteomes; UP000002385; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.790; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR019805; Heat_shock_protein_90_CS.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00298; HSP90; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Stress response.
FT   CHAIN           1..626
FT                   /note="Chaperone protein HtpG"
FT                   /id="PRO_1000146007"
FT   REGION          1..331
FT                   /note="A; substrate-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          332..544
FT                   /note="B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          545..626
FT                   /note="C"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
SQ   SEQUENCE   626 AA;  69409 MW;  843EA020B5EDCCB8 CRC64;
     MSETVERHEF GAEVGRLLDL VVHALYSDRE IFLRELVANA ADATDRRRFE ALTNEALALP
     SDARVLIAPD KAARTLTISD AGIGMSKEDL AQNLGTIARS GTRAFSQALG ERAAEGGEDQ
     RPSLIGQFGV GFYSAFMVAD RVTVTSRRAG SEEAWTWASD GKGSYTLEPA SREQPGTDIV
     LHMKEDADEY LESYRLDHVV RKWADNIAVP IAIRDAEGKE EAANRGTALW RKPKSEITEE
     QYKEFYRTVS HGFDEPWATL HWRAEGALEF TGLLFVPSMK PFMPMEDDRR SKVRLHVRRM
     FITDEAELLP NWLRFVHGVV DTDDLPLNVS REMLQSTPTL QKIRRAVTTR VINELSSRSK
     NTEKAEEYQK FFENFGPVLK EGIYEDFERR AEIAPLLRFR SSTEGGWTSL PEYVARMKPE
     QEAIYYLVAD DVEALKNSAQ LEGFRARRVE VLLLSDHVDA FWPEQLGKFE DKPLRSVTQG
     SADLAKLKPE GETAEAAPAL DTLVAALKLA LEPDVSDVRT TDRLVDSAVV LATSGMGPDL
     QMQRLLRRAG RGFGGSAPIL EINPRHALIR SLNERAEAGE DLKAEAGTLL DLARVQDGDT
     PRDPVAFARA VAAALAGTAA KPAGSA