ID   HTPG_NOCFA              Reviewed;         652 AA.
AC   Q5Z3N4;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Chaperone protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=Heat shock protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=High temperature protein G {ECO:0000255|HAMAP-Rule:MF_00505};
GN   Name=htpG {ECO:0000255|HAMAP-Rule:MF_00505}; OrderedLocusNames=NFA_1150;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00505}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00505}.
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DR   EMBL; AP006618; BAD54957.1; -; Genomic_DNA.
DR   RefSeq; WP_011206644.1; NC_006361.1.
DR   AlphaFoldDB; Q5Z3N4; -.
DR   SMR; Q5Z3N4; -.
DR   STRING; 247156.NFA_1150; -.
DR   PRIDE; Q5Z3N4; -.
DR   EnsemblBacteria; BAD54957; BAD54957; NFA_1150.
DR   GeneID; 61130957; -.
DR   KEGG; nfa:NFA_1150; -.
DR   eggNOG; COG0326; Bacteria.
DR   HOGENOM; CLU_006684_3_0_11; -.
DR   OMA; MRRMKEM; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.790; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF00183; HSP90; 2.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome;
KW   Stress response.
FT   CHAIN           1..652
FT                   /note="Chaperone protein HtpG"
FT                   /id="PRO_0000224219"
FT   REGION          1..351
FT                   /note="A; substrate-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          352..568
FT                   /note="B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          569..652
FT                   /note="C"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
SQ   SEQUENCE   652 AA;  74542 MW;  B0EBDDD93D43146C CRC64;
     MTEHVEQLEF QAETHQLLEL MIHSVYSNKD TFLRELISNA SDALDKLRLE SFKDKDLHVD
     TADLHIELEV DKDNRILTVR DNGIGMSRAE VVDLIGTLAK SGTAELRRKL SEAKSEAAAE
     ELIGQFGIGF YSTFMVADKV TLTTRKAGET GGTRWESSAG SSTYTIEDLA EAPQGTAVSL
     HLKPADEEDH LYDYTQEWKL REIVKKYSDF IAWPIRMQVE RTVTEGEGED KQEKTIVEEQ
     TLNSRKALWT RPRGEVSDEE YKEFYKHVSH AWDEPLEIIP LKAEGTFEYQ ALLFLPSQAP
     FDLFTREHKR GVQLYVKRVF IMDNCEELMP EYLRFVKGVV DAQDLSLNVS REILQQDRQI
     QMIRKRLVKK VLATVKDLQQ AEDQSKYQTF WREFGRVLKE GLLSDFDNRE TILQVSSFAS
     THSDSELTTL AQYVERMPEG QDAIYYMTGE SRQQVESSPH MEAFKAKGRE VLILTDPVDE
     MWVGSVPEFD GKRFQSIAKG EVDLESEEEK KASEALREQQ DKEFADLLSW LGKTLEENIK
     EVRLTNRLTT SPACLVGDVF DFTPMLERMY RASGQPVPVS KRILELNPTH PLVTGLRDAY
     DQRKQDADEG KVPELTETAE LLYGTAVLAE GGELKDPARF AHILTDRLTR TL