ID   3SX_DENPO               Reviewed;          57 AA.
AC   A0A4P1LYC9;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   03-JUL-2019, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Dendroaspis polylepis MT9 {ECO:0000312|PDB:6R5M};
DE   AltName: Full=Three-finger toxin;
DE            Short=3FTx;
OS   Dendroaspis polylepis polylepis (Black mamba).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8620;
RN   [1] {ECO:0000312|PDB:6R5M}
RP   X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), AND DISULFIDE BOND.
RA   Tepshi L., Ciccone L., Ciolek J., Triquigneaux M., Zoukimian C.,
RA   De Waard M., Beroud R., Servent D., Gilles N., Stura E.A.;
RT   "Crystal structure of toxin MT9 from mamba venom.";
RL   Submitted (NOV-2017) to the PDB data bank.
CC   -!- FUNCTION: May have toxic activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. {ECO:0000305}.
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DR   PDB; 6R5M; X-ray; 1.90 A; A/B/C=1-57.
DR   PDBsum; 6R5M; -.
DR   AlphaFoldDB; A0A4P1LYC9; -.
DR   SMR; A0A4P1LYC9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..57
FT                   /note="Dendroaspis polylepis MT9"
FT                   /id="PRO_0000448642"
FT   DISULFID        3..22
FT                   /evidence="ECO:0000269|Ref.1, ECO:0007744|PDB:6R5M"
FT   DISULFID        17..36
FT                   /evidence="ECO:0000269|Ref.1, ECO:0007744|PDB:6R5M"
FT   DISULFID        38..49
FT                   /evidence="ECO:0000269|Ref.1, ECO:0007744|PDB:6R5M"
FT   DISULFID        50..55
FT                   /evidence="ECO:0000269|Ref.1, ECO:0007744|PDB:6R5M"
FT   STRAND          2..4
FT                   /evidence="ECO:0007829|PDB:6R5M"
FT   STRAND          12..16
FT                   /evidence="ECO:0007829|PDB:6R5M"
FT   STRAND          18..20
FT                   /evidence="ECO:0007829|PDB:6R5M"
FT   STRAND          22..27
FT                   /evidence="ECO:0007829|PDB:6R5M"
FT   STRAND          30..37
FT                   /evidence="ECO:0007829|PDB:6R5M"
FT   STRAND          45..50
FT                   /evidence="ECO:0007829|PDB:6R5M"
SQ   SEQUENCE   57 AA;  6364 MW;  AAC9D99360779655 CRC64;
     TICHIQISKT HGILKTCEEN SCYKMSVRGW IIGRGCGCPS AVRPRQVQCC TSDKCNY