ID   HTPG_WIGBR              Reviewed;         638 AA.
AC   Q8D228;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Chaperone protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=Heat shock protein HtpG {ECO:0000255|HAMAP-Rule:MF_00505};
DE   AltName: Full=High temperature protein G {ECO:0000255|HAMAP-Rule:MF_00505};
GN   Name=htpG {ECO:0000255|HAMAP-Rule:MF_00505}; OrderedLocusNames=WIGBR5270;
OS   Wigglesworthia glossinidia brevipalpis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Wigglesworthia.
OX   NCBI_TaxID=36870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12219091; DOI=10.1038/ng986;
RA   Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M.,
RA   Aksoy S.;
RT   "Genome sequence of the endocellular obligate symbiont of tsetse flies,
RT   Wigglesworthia glossinidia.";
RL   Nat. Genet. 32:402-407(2002).
CC   -!- FUNCTION: Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00505}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00505}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00505}.
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DR   EMBL; BA000021; BAC24673.1; -; Genomic_DNA.
DR   RefSeq; WP_011070331.1; NC_004344.2.
DR   AlphaFoldDB; Q8D228; -.
DR   SMR; Q8D228; -.
DR   STRING; 36870.25166483; -.
DR   EnsemblBacteria; BAC24673; BAC24673; BAC24673.
DR   KEGG; wbr:htpG; -.
DR   eggNOG; COG0326; Bacteria.
DR   HOGENOM; CLU_006684_3_0_6; -.
DR   OMA; MRRMKEM; -.
DR   OrthoDB; 246194at2; -.
DR   Proteomes; UP000000562; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.790; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR019805; Heat_shock_protein_90_CS.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00298; HSP90; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome;
KW   Stress response.
FT   CHAIN           1..638
FT                   /note="Chaperone protein HtpG"
FT                   /id="PRO_0000063024"
FT   REGION          1..344
FT                   /note="A; substrate-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          345..560
FT                   /note="B"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
FT   REGION          561..638
FT                   /note="C"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00505"
SQ   SEQUENCE   638 AA;  75168 MW;  96F76E468EFC55ED CRC64;
     MQKKETLEFQ SEVKQLLNLM IHSLYSNKEI FLRELISNAS DALDKLRFLS ISDEKIKIKQ
     NKLCIFIDYD KNKKSITIQD NGIGMSKKEV IENLGTIAKS GTKSFIKSIE KSNSEKNNQL
     IGKFGVGFYS VFIVSEKVLV LTRSFKENEK NGVLWESSGK GEYTISNIIK KDVGTEITIF
     LKESEKEFCD ELNIKNIVLK YSNHINFPIK LKTKITKDNK ILTPEEKKSY TWKQINTGKS
     LWSKKKSEIK DIEYKEFYKN FFNDNYDPLI WSHNHVEGKQ EYVSLLYIPR KASWDIWNRE
     HKHGLKLYVK KVFIMDQSSE FIPNYLRFIK GIIDSNDLPL NVSREILQNN ENIYKIKINL
     TKKALLMLEN LSKNHPDEYK LFWKEFGLIL KEGPSEDIKN YENVIKLFRF SSTYINSENQ
     EVSLEDYVKR MQSGQNKIFY ITSDNYLSAK NNPHLEKLKE KKIEVLLLFD RIDEWMMNYM
     TEFKKIKFQS ISKYSSYLEN IFKDENNDQK NTEQKLSTII LRIKSYLKDR VKDVRFTSKL
     TNSPSTVTTD ENDITTQMSK LLISTGQESP EIKYIFELNA NHPIIKHVFN IEDKNIFNNW
     IELLFEESIL SERGNLDDPN KFIHRINNLL LSNIIRLN