ID   HTR18_HALS3             Reviewed;         816 AA.
AC   B0R474;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Transducer protein Htr18;
GN   Name=htr18; OrderedLocusNames=OE_2195F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   METHYLATION.
RC   STRAIN=R1 / S9;
RX   PubMed=18514223; DOI=10.1016/j.jmb.2008.04.063;
RA   Koch M.K., Staudinger W.F., Siedler F., Oesterhelt D.;
RT   "Physiological sites of deamidation and methyl esterification in sensory
RT   transducers of Halobacterium salinarum.";
RL   J. Mol. Biol. 380:285-302(2008).
CC   -!- FUNCTION: Potentially involved in chemo- or phototactic signal
CC       transduction. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Methylated by CheR. {ECO:0000269|PubMed:18514223}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; AM774415; CAP13539.1; -; Genomic_DNA.
DR   RefSeq; WP_012289229.1; NC_010364.1.
DR   AlphaFoldDB; B0R474; -.
DR   SMR; B0R474; -.
DR   EnsemblBacteria; CAP13539; CAP13539; OE_2195F.
DR   GeneID; 5952703; -.
DR   KEGG; hsl:OE_2195F; -.
DR   HOGENOM; CLU_000445_107_19_2; -.
DR   OMA; HESMAAI; -.
DR   PhylomeDB; B0R474; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 2.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Membrane; Repeat; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..816
FT                   /note="Transducer protein Htr18"
FT                   /id="PRO_0000429082"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          303..356
FT                   /note="HAMP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          423..476
FT                   /note="HAMP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          495..731
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          399..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          790..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..419
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   816 AA;  87061 MW;  A1CF7B3FA9FC53B7 CRC64;
     MALGTYVPTA IRTSLLRKAA VVIVTIMLVL VGVGVFTTQA VSTQVTEQRD TELLTSTEQE
     AEALEEWIGR QRSATQYLSQ DNAIQSAPQA DKSEVLSTRI SGLTETAAAL HYVNLSTDTI
     RASTDAAVEG DTYTSYSIPW RGEGLSFYGG GDVITSSVFN YRGTPVMAFA SKQPGSDNAV
     FVFHSVETRG EAFSRNIDGS YTQVVDIEGT VQIAADESAI SSAYGAGRDA PVIATGLTTN
     SGIETRDGLL VGHAKVEGTD WVLLKHAPTS NAYALEGDVQ RNIVVLIVTA VAGLGALVLV
     IGRDALTALT DMSDRAEAIA AGDIDTAIEE TTRIDEVGDL RRSFRDIQEY LQTVAGQADA
     LAEQDFDADA LDKSVPGRLG ESLETMHWDL ETAIADLEDA QETAEQSRKE AEQSREEAEA
     LAAALESQAQ DIRETVEHAA DGDLTQRLET DTDHESMAAI ATALNSLLEE LEGTIHRIQR
     FSKDVAESSD HITTSAEEVK RASGQVSESV QEMSADARQQ NGIVQDVSDE MTDLSATIEE
     IASSSDEVAA KSNDAVSVGQ SGRARSQDAI EEMNAVDEQA KRTIAEMEAL DDEMTEIGEI
     VTLIDDIAEQ TSMLALNASI EAARAGEAGE GFAVVADEIK SLSKETTEAT QEIESLIADV
     QDSTTDAVTD MQEMGDRLSE GKSTVTDTVE TIDTIVERIE EANGGVQTIN TATDEQATTT
     EEVVTMVDEV GSISDDTTAR AEDAAAAAEE QTASLTEVTN RIQDLSDQST DLYELLSDFT
     VREDHAVADG GAENTTGAFV RSASTDHSRD ATHHDT