HTR1_HALMA
ID HTR1_HALMA Reviewed; 528 AA.
AC Q5UXM8;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 2.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Sensory rhodopsin I transducer;
DE AltName: Full=MCP domain signal transducer 1;
DE Short=HmHtrI;
GN Name=htr1; OrderedLocusNames=rrnAC3281;
OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS B-1809) (Halobacterium marismortui).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=272569;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX PubMed=15520287; DOI=10.1101/gr.2700304;
RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA Hood L., Ng W.V.;
RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT Dead Sea.";
RL Genome Res. 14:2221-2234(2004).
RN [2]
RP INDUCTION, AND IDENTIFICATION.
RX PubMed=20802037; DOI=10.1128/jb.00642-10;
RA Fu H.Y., Lin Y.C., Chang Y.N., Tseng H., Huang C.C., Liu K.C., Huang C.S.,
RA Su C.W., Weng R.R., Lee Y.Y., Ng W.V., Yang C.S.;
RT "A novel six-rhodopsin system in a single archaeon.";
RL J. Bacteriol. 192:5866-5873(2010).
RN [3]
RP SUBCELLULAR LOCATION, FUNCTION, AND INTERACTION WITH SOP1.
RX PubMed=23474528; DOI=10.1016/j.jphotobiol.2013.02.002;
RA Fu H.Y., Lu Y.H., Yi H.P., Yang C.S.;
RT "A transducer for microbial sensory rhodopsin that adopts GTG as a start
RT codon is identified in Haloarcula marismortui.";
RL J. Photochem. Photobiol. B 121:15-22(2013).
CC -!- FUNCTION: Transduces signals from the phototaxis receptor sensory
CC rhodopsin I (Sop1). {ECO:0000269|PubMed:23474528}.
CC -!- SUBUNIT: Interacts with Sop1. {ECO:0000269|PubMed:23474528}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23474528};
CC Multi-pass membrane protein {ECO:0000269|PubMed:23474528}.
CC -!- INDUCTION: Expressed constitutively throughout the growth phases, both
CC in presence and absence of white light. {ECO:0000269|PubMed:20802037}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAV47975.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY596297; AAV47975.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_049939098.1; NZ_CP039138.1.
DR AlphaFoldDB; Q5UXM8; -.
DR SMR; Q5UXM8; -.
DR STRING; 272569.rrnAC3281; -.
DR EnsemblBacteria; AAV47975; AAV47975; rrnAC3281.
DR GeneID; 40154077; -.
DR KEGG; hma:rrnAC3281; -.
DR PATRIC; fig|272569.17.peg.3812; -.
DR eggNOG; arCOG06364; Archaea.
DR HOGENOM; CLU_000445_107_18_2; -.
DR Proteomes; UP000001169; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR Pfam; PF00672; HAMP; 2.
DR Pfam; PF00015; MCPsignal; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00304; HAMP; 3.
DR SMART; SM00283; MA; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Methylation; Reference proteome; Repeat;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..528
FT /note="Sensory rhodopsin I transducer"
FT /id="PRO_0000428857"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 55..107
FT /note="HAMP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 142..195
FT /note="HAMP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 214..455
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT MOD_RES 259
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 528 AA; 55853 MW; EF53B3B6C053C55E CRC64;
MTISSVKQSY GAKLGVGYIA TATLLITVGV VTQDVASTVV AGIAGLLTLG SINAAETVAS
ITELSAQTQR VADGDLDIEI DSTRTDEFGD LADSIEQMRV SLRDRLSEME AARADLEQAQ
TDANEAQAEA EAAEEEAKEL ATAYQDIATE YGTVMAAAAD GDLTQRVDVA TEYDAMETVG
QSFNRMMDEL QETIETVTAV SKRITTETDE ITETSRRVQQ EVDAAVETVA DIQTQATDQQ
TKLESAAVDI QDVSASAEEI AATIDDLADR SSEVEEASSD ARTASETALT EMDQIQADAA
DAVTQVETLQ QRMAEITDIA DIISEIAEQT NMLALNASIE AARAGGQGSG ADGNGFSVVA
DEVKSLAEET QSRADEIATV IAEVSEQTEE VTDSIQATET RVETGTETVE SALSEIATIA
EAVDDISASI EEMRETTSEQ ADTVQATADS IADVTEASAE TATTAEEMST QIRRQRDVVK
SISDSLDSFR ETAVDDLESR VRLFTINTDT TAASQTRAVG SPSIGGDD
