ID   HTR2_HALVA              Reviewed;         433 AA.
AC   P42258;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Sensory rhodopsin II transducer;
DE   AltName: Full=HTR-II;
DE   AltName: Full=Methyl-accepting phototaxis protein II;
DE            Short=MPP-II;
DE   Flags: Fragment;
GN   Name=htrII;
OS   Haloarcula vallismortis (Halobacterium vallismortis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=28442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29715 / DSM 3756 / JCM 8877 / NBRC 14741 / NCIMB 2082;
RX   PubMed=7708770; DOI=10.1073/pnas.92.7.3036;
RA   Seidel R., Scharf B., Gautel M., Kleine K., Oesterhelt D., Engelhard M.;
RT   "The primary structure of sensory rhodopsin II: a member of an additional
RT   retinal protein subgroup is coexpressed with its transducer, the
RT   halobacterial transducer of rhodopsin II.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:3036-3040(1995).
CC   -!- FUNCTION: Transduces signals from the phototaxis receptor sensory
CC       rhodopsin II (SR-II) to the flagellar motor. Responds to light changes
CC       through the variation of the level of methylation. Also acts as a
CC       chemotransducer.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; Z35308; CAA84549.1; -; Genomic_DNA.
DR   AlphaFoldDB; P42258; -.
DR   SMR; P42258; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Chromophore; Membrane; Methylation;
KW   Photoreceptor protein; Receptor; Sensory transduction; Transducer;
KW   Transmembrane.
FT   CHAIN           <1..433
FT                   /note="Sensory rhodopsin II transducer"
FT                   /id="PRO_0000110554"
FT   DOMAIN          58..111
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          130..366
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          24..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   433 AA;  45935 MW;  90507B8897D943C0 CRC64;
     EDEFGTLYAA FDNMRANLRT QISEAETAKQ EAEAAKEQAQ AAREDVESER NEMEALTGHL
     ELKAQQYSDA LDAAANGDLT ARVKTDSMND AMAEVGEDIN TTLDALEDTI ADMKAFATNV
     IQSSDRVNSN AERVDRASKQ VSKSINEIFE GTTEQNEGLE SAAAEMQNLS ATAQQVASSA
     QQVADTSQSA AKVGEDGREA AQEAIAEMSA IEAETGETVE EINALDDELD EIGEIVGVIT
     SIVEQTNMLA LNASIEAAHA DGDGEGFAVV ADEIKGLAEE TKEAAADIEG RIEAIQEQAG
     DTVETMESTS TRITEGVSTV EETVDALETI VEYTEEVDTG IQEIDRATEE QARTAQDVMG
     TIDDLTTISQ QTATEADTVA GAAQDQSASI EEVSDSATEL RQRADDLESL LDRFTVENSA
     GTGTDSTAAV GDD