HTR2_MAGO7
ID HTR2_MAGO7 Reviewed; 110 AA.
AC G5EHQ6;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 25-MAY-2022, entry version 41.
DE RecName: Full=Host transcription reprogramming factor 2 {ECO:0000303|PubMed:33203871};
DE AltName: Full=Secreted nuclear effector HTR2 {ECO:0000303|PubMed:33203871};
DE Flags: Precursor;
GN Name=HTR2 {ECO:0000303|PubMed:33203871};
GN ORFNames=MGCH7_ch7g1049, MGG_10280;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
RN [2]
RP FUNCTION, INDUCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=33203871; DOI=10.1038/s41467-020-19624-w;
RA Kim S., Kim C.Y., Park S.Y., Kim K.T., Jeon J., Chung H., Choi G., Kwon S.,
RA Choi J., Jeon J., Jeon J.S., Khang C.H., Kang S., Lee Y.H.;
RT "Two nuclear effectors of the rice blast fungus modulate host immunity via
RT transcriptional reprogramming.";
RL Nat. Commun. 11:5845-5845(2020).
CC -!- FUNCTION: Secreted effector that translocates into the nuclei of host
CC cells to reprogram the expression of immunity-associated genes by
CC binding on effector binding elements (EBEs) in rice (PubMed:33203871).
CC Binds the 5'-CCACCTCC-3' EBE of promoters from targeted rice genes and
CC probably recruits a yet to determine host repressor (PubMed:33203871).
CC Causes ambivalent immunity with increased susceptibility to the
CC hemibiotrophic pathogens Magnaporthe oryzae and Xanthomonas oryzae pv.
CC oryzae, but enhances resistance to Cochliobolus miyabeanus, a
CC necrotrophic pathogen (PubMed:33203871). {ECO:0000269|PubMed:33203871}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33203871}. Host
CC nucleus {ECO:0000269|PubMed:33203871}. Note=Secreted via the biotrophic
CC interfacial complex (BIC) and translocated into the nuclei of initially
CC penetrated and surrounding cells. {ECO:0000269|PubMed:33203871}.
CC -!- INDUCTION: Expressed during multiple stages of host plant infection,
CC including the prepenetration, early biotrophy, late biotrophy,
CC transition and necrotrophy. {ECO:0000269|PubMed:33203871}.
CC -!- DISRUPTION PHENOTYPE: Does not affect vegetative growth, conidiation,
CC conidial germination, nor appressorium formation, but leads to
CC significantly reduced virulence to rice. {ECO:0000269|PubMed:33203871}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000230; EAQ71642.1; -; Genomic_DNA.
DR EMBL; CM001237; EHA45816.1; -; Genomic_DNA.
DR RefSeq; XP_003720559.1; XM_003720511.1.
DR AlphaFoldDB; G5EHQ6; -.
DR EnsemblFungi; MGG_10280T0; MGG_10280T0; MGG_10280.
DR GeneID; 2681932; -.
DR KEGG; mgr:MGG_10280; -.
DR VEuPathDB; FungiDB:MGG_10280; -.
DR HOGENOM; CLU_2171573_0_0_1; -.
DR OrthoDB; 1295758at2759; -.
DR Proteomes; UP000009058; Chromosome 7.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Host nucleus; Metal-binding; Reference proteome; Repressor; Secreted;
KW Signal; Transcription; Transcription regulation; Virulence; Zinc;
KW Zinc-finger.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..110
FT /note="Host transcription reprogramming factor 2"
FT /id="PRO_5010834276"
FT ZN_FING 68..96
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 88..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 110 AA; 11989 MW; 9DA0B9C41EE973DD CRC64;
MHLKASSILA LLVIGANAYP ASANSAAALV PEPQQPEAPA VAGSTVGAQV DIHHPRLEAR
YGRDEPQIMC GYCGKRFWNK PDLEKHIKLK PSKGGHKGQP YKEHSWNRPT