ID   HTR4_HALSA              Reviewed;         778 AA.
AC   P0DMI4; Q48319; Q9HR92;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Transducer protein Htr4;
DE   AltName: Full=HTP VI;
GN   Name=htr4; Synonyms=htpVI; OrderedLocusNames=VNG_0806G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Potentially involved in chemo- or phototactic signal
CC       transduction. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Methylated by CheR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; AE004437; AAG19266.1; -; Genomic_DNA.
DR   PIR; F84237; F84237.
DR   RefSeq; WP_010902562.1; NC_002607.1.
DR   AlphaFoldDB; P0DMI4; -.
DR   SMR; P0DMI4; -.
DR   STRING; 64091.VNG_0806G; -.
DR   PaxDb; P0DMI4; -.
DR   EnsemblBacteria; AAG19266; AAG19266; VNG_0806G.
DR   GeneID; 5952701; -.
DR   KEGG; hal:VNG_0806G; -.
DR   PATRIC; fig|64091.14.peg.618; -.
DR   HOGENOM; CLU_000445_107_19_2; -.
DR   OMA; MWNEQNE; -.
DR   OrthoDB; 10018at2157; -.
DR   PhylomeDB; P0DMI4; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW   Repeat; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..778
FT                   /note="Transducer protein Htr4"
FT                   /id="PRO_0000110553"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..296
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        318..778
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          318..370
FT                   /note="HAMP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          412..465
FT                   /note="HAMP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          484..720
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          376..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         522
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         739
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   778 AA;  82077 MW;  D752278727A4FA79 CRC64;
     MSIRSFAHRI LRRALPGFVR RSYLAKFGVA LLAVVVCISA AGGVMYLNTS EHLQQSSRTE
     LKKAAELSSS AVDNWHDERT NNARMLAQYG VFDNDNATEV QQFFTDEQHH LPSDVRDIHY
     VSLTDARVIT STDAGLRNAS FGSEAAPWSR QQLTPGDDGV FVSQPYVNDG ITEVAYVARV
     SSTPGRRTAV VMTASLAAIS SSFWDPTPHS FTQLVDGTGS VIADDSKRAT RQPYVENATS
     PIVGARAVGF QPAAQAAKEM DQAHETAYAP VDGTPWVVTL HVPTSEAYGL ASNMAENVLL
     ILGIALAGLV FIALTLGRGT VRALNDLEAK AAALERGEYD TDLDVARVDE LGRLFEAFAS
     LRDTVQARIR DANEQQVDAE AARSEAEAAQ ADAEAAQAEA EAAREESEAQ ARRLETTAEA
     FSETMRAYAA GDLTVRLDAD VEQAAMADIA AAFNEMAADM EATIADVVAF ADEVATASTD
     ASDSAAAVEQ TGRDVSDAVG RIRDRAADQR DQLEAVASET DEMSATIEEV AASADQVAET
     SQRAAALGDD GQAAAQDAVA QLEEIEDETQ AAATAVDDLE AKMSEIETIV AAITDIAEQT
     NMLALNANIE AARADQDGDG FAVVADEVKD LADESKASAA EIEALVAEVR AQTETSVAAM
     DRIQERVSDG VETVSETERS LSEIAGRIAE ADTGVQEISN AMDDQAASVS DVTTAVGDVA
     ALGEETATEA ESTADAAAEQ ATTLSDVAAQ TETLAEHAVA LREHAAQFEV AADNEPGA