HTR5A_DANRE
ID HTR5A_DANRE Reviewed; 1998 AA.
AC Q8JFV4; Q7SXY8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=HEAT repeat-containing protein 5A;
GN Name=heatr5a; ORFNames=si:busm1-142b24.3, si:dz142b24.3, zgc:63665;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8JFV4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8JFV4-2; Sequence=VSP_029688, VSP_029689;
CC -!- SIMILARITY: Belongs to the HEATR5 family. {ECO:0000305}.
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DR EMBL; AL593845; CAD32863.2; -; Genomic_DNA.
DR EMBL; BC055194; AAH55194.1; -; mRNA.
DR RefSeq; NP_956772.2; NM_200478.2. [Q8JFV4-1]
DR AlphaFoldDB; Q8JFV4; -.
DR STRING; 7955.ENSDARP00000107674; -.
DR PaxDb; Q8JFV4; -.
DR PRIDE; Q8JFV4; -.
DR GeneID; 368728; -.
DR KEGG; dre:368728; -.
DR CTD; 25938; -.
DR ZFIN; ZDB-GENE-030616-152; heatr5a.
DR eggNOG; KOG1822; Eukaryota.
DR HOGENOM; CLU_172655_0_0_1; -.
DR InParanoid; Q8JFV4; -.
DR OrthoDB; 71064at2759; -.
DR PhylomeDB; Q8JFV4; -.
DR PRO; PR:Q8JFV4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040108; Laa1/Sip1/HEATR5.
DR PANTHER; PTHR21663; PTHR21663; 2.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..1998
FT /note="HEAT repeat-containing protein 5A"
FT /id="PRO_0000311992"
FT REPEAT 811..848
FT /note="HEAT 1"
FT REPEAT 1025..1062
FT /note="HEAT 2"
FT REGION 1149..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1608..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1608..1626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 108..111
FT /note="FLPT -> TRLS (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_029688"
FT VAR_SEQ 112..1998
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_029689"
SQ SEQUENCE 1998 AA; 216705 MW; 4E1CEA7BDFAE97C8 CRC64;
MEQAHSLLLN EEACSQLPEH QRAEFVFEWL RFLKKLLPAT DRADVKQKQK RLVEQLTTVL
TSSPGPPTRL LLAQCLALVY RVGDSLTSSL TVDRCNDIIR SKDDSPSFLP TRLAAVACLG
ALYEQLGRLL INSFKETTTN LLKAMRSAES QGRCEIMLCV ERILRGLGVS AVSCHRDIYK
AARTGLTDRS MAVRCAAAKC LLELQREAVF LWSTELDNVA TLCFRALEGS NYDVRVSISK
LLGTLLASAL EPRQAIAPRP GSKRSSLEEV MELLSSGFLR GGAGFLRASG DMLKGTSSVS
RDVRVGITQT CVVFVSILGG VWLETHFSRL LSLLMEWASH TRATQYPADA VSCRCCVSFI
LRATLGTLLG EKAQIAAAKE ICQVISKQKR VVDASLHEGN METRVSPADV AASQHVLVCA
LLELGSLVQD LSSTAAPLLQ DTGIGMLDTV ISVLLHPSAS ARLASAWCLR CIAVGMPAQV
AVLLDRCVER LNALKSCPEA VAGYSAAIAA LLGAVQLSPL GISHSKGKMV MTLAEDLLRS
AAQNSRISIQ RTQGGWLLLG ALSTLGPTVM EHHLPRLLLL WKCAFPLSVK DVEMELRRGD
SFTWQVTLEG RAGALCAIKS LVVHCKELLT DDVICRFVPL LSCAVALLTQ LPSIIKSYGN
QIKNAATVFK LRLYEILKLL QPKIYEESFG TVLKQLLNDL TGPEITACAE RNLLPSLCYS
QDLALLGPGL QDMDQRYIEE QLHGGGSGGG TLEYDSFTIF EKSQEVLEQF CEFVRQLKGA
RQQTVQIHVT AAFFCTLKSL ASSRRELGPE EVQRPALSLL LGALEGSNPL LRCMAAEGLA
RLVQVLIDPG FTVSLTLMSF DKLKTARDAI TRTGHALALG TVYRYLGGIS SPQYLSACVG
VLFTLSQDNT SPEVQMWALH ALSTVVDLAG PLYHSHLEAS FTLVLRLLLS TPHTHVEVQQ
SLGRCLNALI TSVGPDLQGE GPGVCAVRTS CLVGCAVMQD SQDCLVQALA ISCLQQLHMF
APRFVNLSSL VPSLCINLCS SYLSLRRAVV ACLRQLAQRE AVEVSEHAVA LVKELPRRDN
TQLDVTIKEV GLEGALFSLL DRESDPRLCR DIQETLVHMM SSAAESKLAH WLKLCKDVLS
ASADSAAAAS VETQQEEDGD RYDDSSAFHA KSESSGPFNN LRWSTRVFSM ECVCRIIAQC
ENRDSAHFNM ALAQEQRLHE STDFLVLHLA DLIRMAFMAS TDHSDQLRLA GLQTLLVIIR
KFSNVPEPEF PGHVILEQYQ ANVGAALRPA FHVDAPPNVT AKACQVCSAW IASGVISDLR
DLRRVHQLLA SSLAKVQVGR DVPSQLYNES TFTMESLAVL KAWAEVYITA VQGSRQRDSP
VSHQQQQSEE AGTAGQAGAG LLKLVQTDLA TLSRLWLAAL QDHALLTLPP HYSSHLPSTG
GSFYTAETVE QARPHYYSAW ATILHATALW LNSTGFIVVD EGPANLSRPV TPTSMGQSTS
LSNVKSPEDI NSDRLHLILG ISVEFLCSPH SGDQMENIHS CLQALQALLE VPWPRSKVGN
DQALSVELLS ILHRLIVTRE SPSIQLAVLE LVQQIICAAQ EHVREKRHSA EVDDGAAEKE
TVPEFGEGRD TGGLVPGRSL VFGALELCLC TLVRKLPQLS PKLTGSPTGR GGQTCSLSAT
DCRLVTSALA ILSELPSICS PEGSVSVLPT VLYLLLGVLK EAVKGSVGTE SGQLVSGILQ
ALRTLLTSPM SRAEKSRGAW TQLLQCALHT LLESWSTDKV EPGVDEVTML TSLTIFLLYA
SAEVTSVEPL QTRCIQTFRA SLDSKDPVVL SRSYQLLLSL FQGPAPVARP FILALGGRLV
SQLEEAEKSR PQGPAELQAV QDAIRALEAL VFAADETHRP QLVAVLLPIL ISLLLDENAL
ASAPAASRSL HESALRDLMR IGPQHSAVLK ALMASAPHMK ARLEAAVKGN QESVNSKAQA
PPAISKNTPS IQLKINFL
