ID   HTR5A_XENTR             Reviewed;        2021 AA.
AC   A0JP94;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=HEAT repeat-containing protein 5A;
GN   Name=heatr5a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HEATR5 family. {ECO:0000305}.
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DR   EMBL; BC127310; AAI27311.1; -; mRNA.
DR   RefSeq; NP_001090667.1; NM_001097198.1.
DR   AlphaFoldDB; A0JP94; -.
DR   STRING; 8364.ENSXETP00000030881; -.
DR   PaxDb; A0JP94; -.
DR   GeneID; 100036639; -.
DR   KEGG; xtr:100036639; -.
DR   CTD; 25938; -.
DR   Xenbase; XB-GENE-5868140; heatr5a.
DR   eggNOG; KOG1822; Eukaryota.
DR   InParanoid; A0JP94; -.
DR   OrthoDB; 71064at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040108; Laa1/Sip1/HEATR5.
DR   PANTHER; PTHR21663; PTHR21663; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..2021
FT                   /note="HEAT repeat-containing protein 5A"
FT                   /id="PRO_0000311993"
FT   REPEAT          795..836
FT                   /note="HEAT 1"
FT   REPEAT          1059..1096
FT                   /note="HEAT 2"
FT   REGION          1503..1528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1989..2012
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1508..1523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2021 AA;  219789 MW;  83B1F85ED22C6438 CRC64;
     MELEERGLQL LDVAELEEPQ RGLRVLEWLR HLRRVLPVIT RAEIKENQKQ LVEQLLLVMM
     GFPGPPARRL LAYNMAFVYS SGDTFSVYET IDRCNDVIRS KDDSPSYLPS KLAAVACLGA
     LYQKLGRLLG STFSDTVSNL LKVLRSAESQ GRSEIMLSLE RILKGLGSAA IPCHRDIYKA
     ARSCLTDRSM SVRCSAAQCL LALQKEASFM WGSDLESLAS ICFKAFEGSS YEVRLAVARL
     LGKVLARAMQ GATSPRQNAR KLSLQEVLGL LSTGFLRGNS GFLRGGGDML GGTSVTTRHV
     RLGATQAYIV FIRTLGGHWL ARNVPVLLSH SLELISNPKA IQNPTDAACS RCCISYILRA
     TVGELLGEKA QLEAAREICE VIRKLMKTVD AVLSDSNLET RFCTTDISAS QHVLVCALQE
     LGDLFLGLGT ILAPLLKDSS AGVLDTVLSV SLHPSLSARL AAAWCLRSVI VSLPSLAAPV
     LDRCVERLTA LKSSPEAVSG YSLTAAVLLG SIRLCPLGVP HGKGKVVMSL AKDLLCTASQ
     NSRFSLQRTQ AGWLLIASLM TLGPAVVQSQ LGCLLLLWRS VFPVTPKDLD TERRRGDAFT
     WQVTLEGRAG ALGAMRSFVS HCGELMSEEV LQRLLPPLPC AIALLTLLPS LQKLYGNSLK
     ACSVLYRQRL YQLLVLLPPK TYEESFCAVM KELVADLTSP DYSPGGAAFL LSSVCHPDDL
     VLLGPSFQEC DQRATEEELL LSSGIPGGSL EYDLHAIYEL PSEGESVPKP LPSAFTVIQA
     ASLLFGTLLA HMPESQRPQI LQQLVESIKQ TKGSRQQSVQ LCAMSSLCNF LKHLASSRSN
     LGPEEMRKPC LSLIQAVLEG NSLWLRCAGV ESVARLVQVV DDPTFTAGLI QASFDKLKTA
     RDVVARTSHS LVLGTLHRYL GGINSSQHLA SCVGVLHSLS QDTTSPEVQT WALHSLSVIT
     DLSGPLFNVH IEATLSLLLT ALITTSPSHP EVHRSLGRCL SALVTALGPE LQGNGAVLSS
     QRTSCLLACS VMQENPDCLV QAQGISCLQQ LHMYAPKHVN LSSLVPTLCV HLYSPHLPLR
     RAVLACLRQL AQREAAEVSE HAMTVAKEGH EDLKMEMNMR ELGLEGVLLS LLDRESDQQL
     LRDVKETLLH MQNCTGLSRL SFWLRMLKDI LSASADFAAV ASVDTNQEDE GEVACSDSVL
     TSSKAESLGS SVTPHWKTRI FAMECVCQLI TQCELDGGAH FDMAQAQEMK HKEPERDFLV
     LHLQDLIRMS FMAATDHSEQ LRLVGLQALL LVIHRFAAVP EPEFPGHLIL EQFQANVLAA
     VRPAFNTDTP PDVTARACEV CSAWLASGVV KELADLQRVQ QLLLTSLRRV QVAKETASVY
     SESTTAMESL AVLKAWAEVY IAAMEKQVTQ SKMAEAQNEV LLSLVQAELL TLSGLWLAAL
     QDHALLTLPA ACASQLPSQG GGFYTAETSD AARPHYLLSW APILHASSLW LSSSGFVLPD
     QDEGNGHLSR PVTPTSMGQE RGSQLPADSP EDLNLERFHL ILGISVEFLC CPPVDAPMER
     ITSCLRALKA LLSGMWPKAH IGTDQDLAIE LISVLHRLLL MRESSEVQLL VLEVGRLIVN
     AAQDHVRERR RSAEVDDGAE EKETLPVFGE GHDTGGLVPG HSLVVAALEL CLCILIRQLP
     QLSPHLSGGS VVGKTEPLFS EARLLVASSL GILAELPSLC SPEGSVSVLP TLLYLVVGVL
     QDTTVKFPDG HLTLPVTAAL QALKVIVSSP MSQVEKCRAS WTRLMQSAVS TLLNSWHLER
     QLVPDSVSLL TALTIFLLSA NPEVMSDPGL QNACVQRFQN SIDSKNPTEQ LKCYRLLLSI
     FKHPVPEVVA PYVCSLAPRI MRHLSQAESR KPQSMEELLV LQEGVNLLKT LVSAVEEQNR
     PSMVCMLLHL LISFLLDENA LGSAPHYSRA LHDFGLHSLT SFGASYPTQF RKLMGSSPAL
     RSRLEAALRG NQESLKPKAP SRGTMGGGHG SPSIQLKTNF L