ID   HTR5B_XENTR             Reviewed;        2052 AA.
AC   A1A5F2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=HEAT repeat-containing protein 5B;
GN   Name=heatr5b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of clathrin-coated vesicles (By similarity). Plays
CC       a role in protein trafficking (By similarity).
CC       {ECO:0000250|UniProtKB:Q9P2D3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC       {ECO:0000250|UniProtKB:Q9P2D3}.
CC   -!- SIMILARITY: Belongs to the HEATR5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC128623; AAI28624.1; -; mRNA.
DR   RefSeq; NP_001090701.1; NM_001097232.1.
DR   RefSeq; XP_012817983.1; XM_012962529.2.
DR   AlphaFoldDB; A1A5F2; -.
DR   STRING; 8364.ENSXETP00000041934; -.
DR   PaxDb; A1A5F2; -.
DR   PRIDE; A1A5F2; -.
DR   GeneID; 100036680; -.
DR   KEGG; xtr:100036680; -.
DR   CTD; 54497; -.
DR   Xenbase; XB-GENE-5931269; heatr5b.
DR   eggNOG; KOG1822; Eukaryota.
DR   InParanoid; A1A5F2; -.
DR   OrthoDB; 71064at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000019350; Expressed in 4-cell stage embryo and 13 other tissues.
DR   ExpressionAtlas; A1A5F2; baseline.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040108; Laa1/Sip1/HEATR5.
DR   PANTHER; PTHR21663; PTHR21663; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Protein transport; Reference proteome; Repeat;
KW   Transport.
FT   CHAIN           1..2052
FT                   /note="HEAT repeat-containing protein 5B"
FT                   /id="PRO_0000311996"
FT   REPEAT          848..885
FT                   /note="HEAT 1"
FT   REPEAT          1062..1099
FT                   /note="HEAT 2"
FT   REPEAT          1270..1307
FT                   /note="HEAT 3"
FT   REGION          1183..1203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1423..1442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1531..1557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2052 AA;  222853 MW;  27AC392DC4C37312 CRC64;
     MELAHSLLLK EDALAQITEA KKSVFIFEWL RFLDKVLIAA NKTDIKENQK KLVEQLTGLI
     SSSPGPPTRK LLAKNLATLY SIGDTFTVFQ TLDKCNEMIK NKDDTPAYLP TKLAAVACVG
     AFYEKMGRML GSSFPETVNN LLKSLKGAES QGRSEILMSL QKVLSGLGGA ASSSHRDIYK
     NARSVLTDRS MAVRCATAKC LLELQSEAVF MWTAELENVA TLCFKALEGS NYGVRVAVSK
     LLGTVMATAL MPKQATVMRQ NVKKATLEEV LELMATGFLR GGSGFLKSGG EMLKGGGSIS
     REVRVGVTQA YVVFVTALGG KWLERNFATF LSHVLDLVSH PRATQTHVEA VYSRRCVSFI
     LRATVGSLLG EKAQNAAAKE ICQAISKQMK SVEAVVNDAN NDNKSGTADV SASQHVMVCA
     LQELGSLVQS LNSTASPLIL EPSIGLLDTV TNVLLHPSMA ARLAAAWCLR CVAVALPFQL
     TPLLDRCAER LNNLKNSPEA VSGYSFAMAA LLGGVHQCPL GIPHSKGKMV VGIAEDLLRT
     AAQNSRLSLQ RTQAGWLLLG ALMTLGPSVV RYHLPKMLLL WRNVFPRSLK ELEAEKARGD
     SFTWQVTLEG RAGALCAMRS FVAYCPELLT EDVIRKLMTP IECAMTMMSH ILSVIKAHGA
     HLKASAAMVR LRLYDILALL PPKTYEGNFN VLLRELVAEF TLTDNSSNTT TSLLRSLCHY
     DDSVLLGSWL QETDHKSIED QLQPNSASGS GALEHDPSSI YLRIPAGEAV PGPLPLGVSV
     IDASVALFGV VFPHVSFKHR LQMLDHFAEC VKQAKGVRQQ AVQLNIFTAV LSALKGLAEN
     KSSLGPEEVR KSALTLVMGA LDNPNPILRC AAGEALGRMA QVVGEASFIA RMAQFSFDKL
     KSARDVVSRT GHSLALGCLH RYVGGIGSGQ HLKTSVSILL ALAQDGTSPE VQTWSLHSLA
     LIVDSSGPMY RGYVEPTLSL VLTLLLTVPP SHTEVHQCLG RCLGAIITTV GPELQGNGPT
     ISTIRSSCLV GCAIMQDHSD SLVQAAAISC LQQLHMFAPR HVNLSSLVPC LCVHLGSSHL
     LLRRAAVACL RQLAQREAAE VCEYAMNLAK NAGDKESSGL NINITDTGLE GVLFGMLDRE
     TDRKLCSDIH DTLGHMLSSL AVEKLSHWLQ LCKDVLAASS DVGTTGPVSG GKDDESEKKD
     EMDDDTMFTT LGDDDKSKPF VAPRWATRVF AADCLCRIIL LCENSDKVHF DLAQARAARL
     KNPKNDLLVL HLSDLIRMAF MAATDHSNQL RMAGLQALED IIKKFASVPE PEFPGHVILE
     QYQANVSAAL RPAFSQDTPS DITAKACQVC STWIGSRVVS DLNDLRRVHN LLVSSLDKIQ
     KGKGASSQLY RESAMTMEKL SVLKAWAEVY AVAMNIKKEA ENNPKKALKT SDEDEDDYST
     TDELPPDCLI TLVEPELPTL SRLWLAALKD YALLTLPPEF ASQLPPDGGA FYTPETIDTA
     RLHYRNSWAP ILHAVALWLN CTGFSNSDTA EDGAVAGSQK RTASATLNQP ASTPQGTKSL
     MEVNKNRMHL ILGISIQFFC APRPEEPIEH VTACLQALHI LLESPFARNH IAEDQVIGVE
     LLNVLHRLLL TWDTSSVQLR VTTVVQQIVR AAQHNIQEQR NAQNKDDTSE KETQVLLGEG
     EESGGLIPGK SLVFASMELL MFILVRHMPQ LSSKLSDSPS HIVSKSQQLS EESMRLVAST
     VTILSELPSL CSPAGCMTIL PTILFLITKV LKETAIKTAD NHVPLPVSAA LQGIKTIVTS
     SLAKTEKTQK KWTDLIRSTL ASVLESPLPA DSKHTVDEVS ILTAIVLFLW SASAEIIGVE
     SLQNGCISKF KAALNSSDPW VQAKCYQLLL SVFQHSNRAL STPYIHSLAP IMVENLKAVE
     RKKPKINTEV LAVQEGIKVI ETLVALGEEQ NRVQLLALLV PTLISYLLDV NTFSSASQPS
     KDLHEFALQD LMRIGPLYPQ AFKTVIGAAP ELKARLETAI RASQASKAKA ASRQQAPVIQ
     SAPTIKLKTS FF