ID   HTR6_HALS3              Reviewed;         789 AA.
AC   B0R461;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Transducer protein Htr6;
GN   Name=htr6; Synonyms=htrVI; OrderedLocusNames=OE_2168R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   METHYLATION.
RC   STRAIN=R1 / S9;
RX   PubMed=18514223; DOI=10.1016/j.jmb.2008.04.063;
RA   Koch M.K., Staudinger W.F., Siedler F., Oesterhelt D.;
RT   "Physiological sites of deamidation and methyl esterification in sensory
RT   transducers of Halobacterium salinarum.";
RL   J. Mol. Biol. 380:285-302(2008).
CC   -!- FUNCTION: Potentially involved in chemo- or phototactic signal
CC       transduction. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Methylated by CheR. {ECO:0000269|PubMed:18514223}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM774415; CAP13526.1; -; Genomic_DNA.
DR   RefSeq; WP_010902553.1; NC_010364.1.
DR   AlphaFoldDB; B0R461; -.
DR   SMR; B0R461; -.
DR   PRIDE; B0R461; -.
DR   EnsemblBacteria; CAP13526; CAP13526; OE_2168R.
DR   GeneID; 5954381; -.
DR   KEGG; hsl:OE_2168R; -.
DR   HOGENOM; CLU_000445_107_19_2; -.
DR   OMA; HADSINE; -.
DR   PhylomeDB; B0R461; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 3.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 2.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Membrane; Repeat; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..789
FT                   /note="Transducer protein Htr6"
FT                   /id="PRO_0000429079"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          315..367
FT                   /note="HAMP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          409..462
FT                   /note="HAMP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          481..717
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          763..789
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   789 AA;  83927 MW;  ABE57215065BF4B5 CRC64;
     MSDGITGALR NAASVVAPDA IRRRFGAKFA VAFIVVLVVI AGAGVFAFQS TETTVEHQTT
     RQLAESNQLE ADAIGAWMEQ QRTHARSVSQ DEALRDDRRA APYILLKDQL LPADVVSMHL
     VNETRGTVVA STELAIEGRS LAELDAPWTT AAVPEGPGND SAVWATEQSY RSPVLNDEPV
     MAFASSVPKR EGAHLVVVTR IQPQVDRLSD ANSTRRTTIL NTGDEPVLDS NSRFDAGALT
     DSIAAVRNDT TAATTTVSNG RVYALSATPH TDWVTVTSVD TGEAFAVRDT VGQTVTVLVV
     LAVISLAIVG IALGRHTVTP LKRLRNRAQD IESGTFDVDL STRRIDEVGR LYGSFDDMRV
     SLQDRIQEAE AAVEEANAAK AEAEELRTDA EDAQAEAERA KATAEAASER LQERAADYSE
     VMQAVADGDL TERLDEDADE EAMRAVATEF NAMLDGLEAT IAQVAGFADE VADETLQVAT
     GAEEIETTSQ TVSERIQEIA DGAIQQHDDL ERAAGEMDEL SASIQEVAAS SATVAETAAD
     AVERGEAGRD AAESAIDDMA EIESLSADAV DQILALQERM SDIGDIIEFI TDIAEQTNML
     ALNANIEAAR ADKDGDGFAV VANEVKDLAE ETKQAAADIE SEIQAVQAET DETVADIRAT
     SEHIDDGVST VERAAAAIED TVDAIEDANH GIQEISDATE DQADATQSVV RRVDDVADIS
     QHVTEDAEQV SAAAEEQSAS VAEIARSADD LRDRADALAT TVNQFETRAD ADEPDADTTV
     DASADDTGD