ID   HTR7_HALS3              Reviewed;         545 AA.
AC   B0R6A6; Q48318; Q9HP85;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Transducer protein Htr7;
GN   Name=htr7; Synonyms=htrVII; OrderedLocusNames=OE_3473F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=R1 / S9;
RX   PubMed=8674984; DOI=10.1111/j.1574-6968.1996.tb08197.x;
RA   Rudolph J., Nordmann B., Storch K.F., Gruenberg H., Rodewald K.,
RA   Oesterhelt D.;
RT   "A family of halobacterial transducer proteins.";
RL   FEMS Microbiol. Lett. 139:161-168(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [3]
RP   METHYLATION AT GLU-281.
RC   STRAIN=R1 / S9;
RX   PubMed=18514223; DOI=10.1016/j.jmb.2008.04.063;
RA   Koch M.K., Staudinger W.F., Siedler F., Oesterhelt D.;
RT   "Physiological sites of deamidation and methyl esterification in sensory
RT   transducers of Halobacterium salinarum.";
RL   J. Mol. Biol. 380:285-302(2008).
CC   -!- FUNCTION: Potentially involved in chemo- or phototactic signal
CC       transduction. {ECO:0000269|PubMed:8674984}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Methylated by CheR. {ECO:0000269|PubMed:18514223}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; X95589; CAA64842.1; -; Genomic_DNA.
DR   EMBL; AM774415; CAP14275.1; -; Genomic_DNA.
DR   PIR; T46811; T46811.
DR   RefSeq; WP_010903283.1; NC_010364.1.
DR   AlphaFoldDB; B0R6A6; -.
DR   SMR; B0R6A6; -.
DR   EnsemblBacteria; CAP14275; CAP14275; OE_3473F.
DR   GeneID; 5953097; -.
DR   KEGG; hsl:OE_3473F; -.
DR   HOGENOM; CLU_000445_107_18_2; -.
DR   OMA; GYMNEQV; -.
DR   PhylomeDB; B0R6A6; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Membrane; Methylation; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..545
FT                   /note="Transducer protein Htr7"
FT                   /id="PRO_0000429077"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          164..217
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          236..476
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          111..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         281
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:18514223"
SQ   SEQUENCE   545 AA;  57071 MW;  FDD870389C2F428B CRC64;
     MSGAAVFVDA VVAPLGDAVG AIGFGAAAAL GYRNYRDTDA EAAFWMAFTF ASLLGVTWTV
     SLMLEKAGVA TQIFNLATGP LMATTVAVFA IGGTATLAIV EDMEALVEER AQRRQEAEEE
     RAEAERAREK AEQKQAEAER QTAEAESAKQ DARERSAEIE QLAADLESQA TEVGATLEAA
     SDGDLTARVD ATTDNAEIAE VATVVNDMLT TMERTIDEIQ GFSTNVTTAS REATAGAKEI
     QDASQTVSES VQEIAAGTDD QREQLESVAE EMDSYSATVE EVAATAQSVA DTAADTTDVA
     TAGKQTAEDA IDAIDAVQET MQTTVANVDA LEDLTTEIDD IAELISDIAE QTNMLALNAN
     IEAARAGSGG GSNGDGFAVV ADEVKELATE SQRSAKDIAE LIEEVQSQTA TTVEEIRVAE
     QRVNDGAAAV EETVDAFGAV TENIQETTDG VQEISQAMDE QAQRSERVVS SVDDIATISQ
     ATADRAENVS AASEEQTASI TEVTSSLQSL AAQADTLEDR LNEFRTEATG TAHGEATDAP
     AGQSD