ID   HTR8_HALS3              Reviewed;         643 AA.
AC   B0R5T0;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Transducer protein Htr8;
GN   Name=htr8; Synonyms=htrVIII; OrderedLocusNames=OE_3167F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   METHYLATION.
RC   STRAIN=R1 / S9;
RX   PubMed=18514223; DOI=10.1016/j.jmb.2008.04.063;
RA   Koch M.K., Staudinger W.F., Siedler F., Oesterhelt D.;
RT   "Physiological sites of deamidation and methyl esterification in sensory
RT   transducers of Halobacterium salinarum.";
RL   J. Mol. Biol. 380:285-302(2008).
CC   -!- FUNCTION: Potentially involved in chemo- or phototactic signal
CC       transduction. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Methylated by CheR. {ECO:0000269|PubMed:18514223}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; AM774415; CAP14097.1; -; Genomic_DNA.
DR   RefSeq; WP_010903109.1; NC_010364.1.
DR   AlphaFoldDB; B0R5T0; -.
DR   SMR; B0R5T0; -.
DR   EnsemblBacteria; CAP14097; CAP14097; OE_3167F.
DR   GeneID; 5953014; -.
DR   GeneID; 62886959; -.
DR   KEGG; hsl:OE_3167F; -.
DR   HOGENOM; CLU_000445_107_18_2; -.
DR   OMA; TAWSLIW; -.
DR   PhylomeDB; B0R5T0; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Membrane; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..643
FT                   /note="Transducer protein Htr8"
FT                   /id="PRO_0000429080"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          273..326
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          345..581
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
SQ   SEQUENCE   643 AA;  67291 MW;  1D53F2E18BA02481 CRC64;
     MGESARGGGS AETTGGLAAA VKTYLEYTPT GESIPAAAWR RRHRNVRVFV LAHIPLLLAL
     GLYEGTESAV TGATIPPTPG ILIAAELGIV GALVGLASIP SVSRRGRTAL ASTAVLASSV
     VLVQFSGGFI EAHFHFFVGM AVIAVYEDWL PFALGLVYVV FTHGVFGMIN AERVYNHTAA
     INNPWVWGGI HGAFVLLLAG ALMANWYSTE RSREASQKRL EEARQKAQQV EDLEARQAEI
     EAEKAEAKRL KADAEEAREA AEAQQREVAA LNERLEATAN TYGAAMARAA DGDLSVRLDP
     DVENDAMAAI AASFNEMLDE TETTIREIQA VASDVAAASE DADAGVVEIE DASGQVSETV
     QEIAAGADEQ REKLETVSGE MTDLSAAIEE VAASADSVAE RSHETAAVAG DGEQTAEQAI
     ADSRTVQSAV ESTVQNVEAL DDQLAEISEI VDLISDVAEQ TNMLALNANI EAARADKSGD
     GFAVVADEVK DLAEETRASA GDIEALVADI DAQMQATVTE ARTADESVQD AISAVDAVVD
     AFGTVAENAE ETDTGVQEIS TTTDDQAAST EEAVSMIAEV SDISTATAAD AQQASTAAEQ
     QTTAAATISE NTAALREQAD RLQGLVSTFD VHDESASTAA RSE