ID   HTRAL_STAEQ             Reviewed;         585 AA.
AC   Q5HQE2;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Serine protease HtrA-like;
DE            EC=3.4.21.-;
GN   OrderedLocusNames=SERP0611;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; CP000029; AAW54044.1; -; Genomic_DNA.
DR   RefSeq; WP_001829335.1; NC_002976.3.
DR   AlphaFoldDB; Q5HQE2; -.
DR   SMR; Q5HQE2; -.
DR   STRING; 176279.SERP0611; -.
DR   EnsemblBacteria; AAW54044; AAW54044; SERP0611.
DR   GeneID; 50019136; -.
DR   KEGG; ser:SERP0611; -.
DR   eggNOG; COG0265; Bacteria.
DR   HOGENOM; CLU_027421_0_0_9; -.
DR   OMA; ISREWAK; -.
DR   OrthoDB; 741829at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF13180; PDZ_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Serine protease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..585
FT                   /note="Serine protease HtrA-like"
FT                   /id="PRO_0000252471"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          516..575
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          1..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..112
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        320
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        350
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        435
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   585 AA;  66222 MW;  01E3500A1D978321 CRC64;
     MDNNKKQVIP RSQYRRKRRE YFHNVEREER IRREKIEKEN QAKREQHQTK VNEERVKDNL
     RKARIEKLTQ EEIHQQRDDK SYKQKTLNQN NQMNKSKDDD NKIGEESLHD VRVSSDTSTL
     PHQNKSIKDY DDSGNESKQH TKLTSKESML GVNSNHTEQD SRSTQPYSSK HSYSQPKDKD
     NDNTQQAQFL KKEDKQRNRA ENIKKVNEFK QLVVAFFKEH WPKMLIIIGI IVLLLILNAI
     FTTVNKNDHT NDSAFNGTAK DETTAMKIAE NSVKSVVTVE NDLSNDTTVS DNKNESDNEI
     GSGVVYKKVG DSIYIFTNAH VVGDQEKQKV TYGNDKSVTG KVIGKDKWSD LAVVKAKVAD
     ENIKPMTMGD SNNIKLAEPI LVIGNPLGTD FKGSVSQGIV SGLNRHVPVD IDKNDNYDAL
     MKAFQIDAPV NPGNSGGAVV DRDGRLIGIV SLKIDMHNVE GMAFAIPIND VRKIAKELEH
     KGKVNYPNTE IKIKNVGDLD DSERNAINLP AKVNHGVLIG EVKENGLGDK AGLKKGDVIV
     ELDGKKIEDN LRYRQVIYSH YDDQKTITAK IYRNGAEKNI KIKLK