ID   HTRAL_STAS1             Reviewed;         597 AA.
AC   Q49WF1;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Serine protease HtrA-like;
DE            EC=3.4.21.-;
GN   OrderedLocusNames=SSP1763;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; AP008934; BAE18908.1; -; Genomic_DNA.
DR   RefSeq; WP_011303469.1; NZ_MTGA01000039.1.
DR   AlphaFoldDB; Q49WF1; -.
DR   SMR; Q49WF1; -.
DR   STRING; 342451.SSP1763; -.
DR   PRIDE; Q49WF1; -.
DR   EnsemblBacteria; BAE18908; BAE18908; SSP1763.
DR   KEGG; ssp:SSP1763; -.
DR   PATRIC; fig|342451.11.peg.1759; -.
DR   eggNOG; COG0265; Bacteria.
DR   HOGENOM; CLU_027421_0_0_9; -.
DR   OMA; ISREWAK; -.
DR   OrthoDB; 741829at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF13180; PDZ_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Serine protease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..597
FT                   /note="Serine protease HtrA-like"
FT                   /id="PRO_0000252474"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          485..561
FT                   /note="PDZ"
FT   REGION          1..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        331
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        361
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        447
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   597 AA;  66650 MW;  BB343AE111948ADB CRC64;
     MANDKKHVIP REKYGRKRRE YFHNEEREQR VQMERKARKQ RAEKAEKLAK NNEERVKENL
     RKARIEKLTQ EEIQQQQAMA TKRNSSNSES EFEPSEDNAL NHVSKQQPEE VSPTSDIAKD
     DVEVASTTNE TNGYLKTNEI SNDSDIDVNA STNKDRLHDD YFYSEEAQQS RVNQYIEEDN
     SDKVHNNIAR NHKSGQTDDK SDQHRHSDQP TLIDKVKYFF KEHWAKVLIV LAVILLIVLI
     NAIFNNVDHN GNTKDNIFQS SDNANKEKTY TDTMKSANSA IHSIVTVEND TSNNSSSAEK
     ETQEAGKENE LGSGVVYKKV GDSIFIMTNA HVVGDKKEQK ITYGNNDTSI GKVIGTDKFS
     DIAVVKTKIK SGSDVKSIKM GDSSTLVLGE PIIVVGNPLG VDFKGSVSEG IVSGLNRHVP
     VDIDKDNQYD VLMSAFQMDA PVNPGNSGGG VIDKNGKLIG IASLKIDMDH VEGIAFAIPV
     NDAESIAKQL EAKGEVKYPN TGIKIANVKD MDEATHQSLN LPEEVNKGVV IGDVKDNSLG
     EKSGLQKNDV IVELDGKEVE DNLRYRQIIF SHKDDLDTLP AKIYRDGKEQ DIKIKLK