HTT2_ARATH
ID HTT2_ARATH Reviewed; 252 AA.
AC Q9FJF8; Q8LCY9;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein HEAT-INDUCED TAS1 TARGET 2 {ECO:0000303|PubMed:24728648};
GN Name=HTT2 {ECO:0000303|PubMed:24728648};
GN OrderedLocusNames=At5g18040 {ECO:0000312|Araport:AT5G18040};
GN ORFNames=MCM23.14 {ECO:0000312|EMBL:BAB08403.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP REPRESSION BY TA-SIR850.
RX PubMed=16889646; DOI=10.1111/j.1365-313x.2006.02835.x;
RA Yang L., Liu Z., Lu F., Dong A., Huang H.;
RT "SERRATE is a novel nuclear regulator in primary microRNA processing in
RT Arabidopsis.";
RL Plant J. 47:841-850(2006).
RN [6]
RP REPRESSED BY SIRNA255.
RC STRAIN=cv. Columbia;
RX PubMed=18753245; DOI=10.1099/vir.0.2008/002170-0;
RA Meng C., Chen J., Ding S.-W., Peng J., Wong S.-M.;
RT "Hibiscus chlorotic ringspot virus coat protein inhibits trans-acting small
RT interfering RNA biogenesis in Arabidopsis.";
RL J. Gen. Virol. 89:2349-2358(2008).
RN [7]
RP REPRESSION BY SMALL INTERFERING RNAS, AND INDUCTION BY COLD.
RX PubMed=20622450; DOI=10.1271/bbb.100111;
RA Kume K., Tsutsumi K., Saitoh Y.;
RT "TAS1 trans-acting siRNA targets are differentially regulated at low
RT temperature, and TAS1 trans-acting siRNA mediates temperature-controlled
RT At1g51670 expression.";
RL Biosci. Biotechnol. Biochem. 74:1435-1440(2010).
RN [8]
RP FUNCTION, REPRESSION BY SMALL INTERFERING RNAS, INDUCTION BY HEAT SHOCK,
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=24728648; DOI=10.1105/tpc.114.124883;
RA Li S., Liu J., Liu Z., Li X., Wu F., He Y.;
RT "HEAT-INDUCED TAS1 TARGET1 Mediates Thermotolerance via HEAT STRESS
RT TRANSCRIPTION FACTOR A1a-Directed Pathways in Arabidopsis.";
RL Plant Cell 26:1764-1780(2014).
CC -!- FUNCTION: Mediates both basal and acquired thermotolerance via HSFA1s-
CC directed pathways (e.g. HSFA1A, HSFA1B, and HSFA1D). Triggers the
CC expression of HSFA1A and HSFA1B. {ECO:0000269|PubMed:24728648}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24728648}. Nucleus
CC {ECO:0000269|PubMed:24728648}.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously, including in seedlings,
CC leaves, stems, inflorescences and siliques.
CC {ECO:0000269|PubMed:24728648}.
CC -!- INDUCTION: Target of TAS1 (trans-acting siRNA precursor 1)-derived
CC small interfering RNAs in response to temperature variations, thus
CC reducing both basal and acquired thermotolerance (PubMed:24728648,
CC PubMed:20622450). Up-regulated by cold (at 4 degrees Celsius)
CC (PubMed:20622450). Repressed by trans-acting small interfering RNA (ta-
CC siRNAs) siR850/siRNA255-mediated transcript cleavage (PubMed:16889646,
CC PubMed:18753245). Highly up-regulated in seedlings exposed to heat
CC shock. Induced by HSFA1s-mediated (e.g. HSFA1A, HSFA1B, and HSFA1D)
CC promoter activation (PubMed:24728648). {ECO:0000269|PubMed:16889646,
CC ECO:0000269|PubMed:18753245, ECO:0000269|PubMed:20622450,
CC ECO:0000269|PubMed:24728648}.
CC -!- SIMILARITY: Belongs to the heat induced plant HTT protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM64385.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB015473; BAB08403.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92499.1; -; Genomic_DNA.
DR EMBL; AY050965; AAK93642.1; -; mRNA.
DR EMBL; AY096752; AAM20386.1; -; mRNA.
DR EMBL; AY086314; AAM64385.1; ALT_INIT; mRNA.
DR RefSeq; NP_197305.1; NM_121809.3.
DR AlphaFoldDB; Q9FJF8; -.
DR STRING; 3702.AT5G18040.1; -.
DR PaxDb; Q9FJF8; -.
DR PRIDE; Q9FJF8; -.
DR EnsemblPlants; AT5G18040.1; AT5G18040.1; AT5G18040.
DR GeneID; 831925; -.
DR Gramene; AT5G18040.1; AT5G18040.1; AT5G18040.
DR KEGG; ath:AT5G18040; -.
DR Araport; AT5G18040; -.
DR TAIR; locus:2161568; AT5G18040.
DR HOGENOM; CLU_1005918_0_0_1; -.
DR OrthoDB; 151494at33090; -.
DR PhylomeDB; Q9FJF8; -.
DR PRO; PR:Q9FJF8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJF8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0010286; P:heat acclimation; IMP:UniProtKB.
DR GO; GO:0009409; P:response to cold; IEP:UniProtKB.
DR GO; GO:0009408; P:response to heat; IEP:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IMP:TAIR.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..252
FT /note="Protein HEAT-INDUCED TAS1 TARGET 2"
FT /id="PRO_0000439260"
FT CONFLICT 83
FT /note="R -> K (in Ref. 4; AAM64385)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="R -> I (in Ref. 4; AAM64385)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 28550 MW; 78DF092FA6C60D7F CRC64;
MNMIQRFMQS MAKTRGLCHP DCVKASSEQE DYDASQLSIW WIMLGRKTTR EKWMNQALSS
LSKTCISIWW KMSGIRGKMC REREQPLTVK DCLECAFKKG LPRREHWAHV GCTFKAPPFA
CHIPRVPMKG EVIETKSLDE AFKLLIKQPV GARLHVFSPD LDNVGEGVYE GLSSLSRKES
RYVGLRDVII VAVNKSEGKT VATVKICYKK KTSFVKVCLS RMFVQLGGGE ESQVKEPTGL
LVDFCIPRLS IN
