HTT5_ARATH
ID HTT5_ARATH Reviewed; 178 AA.
AC Q8RY97; Q9C8H7;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein HEAT-INDUCED TAS1 TARGET 5 {ECO:0000303|PubMed:24728648};
GN Name=HTT5 {ECO:0000303|PubMed:24728648};
GN OrderedLocusNames=At1g51670 {ECO:0000312|Araport:AT1G51670,
GN ECO:0000312|EMBL:AEE32697.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP REPRESSION BY SMALL INTERFERING RNAS, AND INDUCTION BY COLD.
RX PubMed=20622450; DOI=10.1271/bbb.100111;
RA Kume K., Tsutsumi K., Saitoh Y.;
RT "TAS1 trans-acting siRNA targets are differentially regulated at low
RT temperature, and TAS1 trans-acting siRNA mediates temperature-controlled
RT At1g51670 expression.";
RL Biosci. Biotechnol. Biochem. 74:1435-1440(2010).
RN [6]
RP INDUCTION BY HEAT SHOCK, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=24728648; DOI=10.1105/tpc.114.124883;
RA Li S., Liu J., Liu Z., Li X., Wu F., He Y.;
RT "HEAT-INDUCED TAS1 TARGET1 Mediates Thermotolerance via HEAT STRESS
RT TRANSCRIPTION FACTOR A1a-Directed Pathways in Arabidopsis.";
RL Plant Cell 26:1764-1780(2014).
RN [7]
RP FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=30778176; DOI=10.1038/s41422-019-0145-8;
RA Liu J., Feng L., Gu X., Deng X., Qiu Q., Li Q., Zhang Y., Wang M., Deng Y.,
RA Wang E., He Y., Baeurle I., Li J., Cao X., He Z.;
RT "An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates
RT transgenerational thermomemory in Arabidopsis.";
RL Cell Res. 29:379-390(2019).
CC -!- FUNCTION: Mediates both basal and acquired thermotolerance. Involved in
CC the mechanisms necessary for quick response to heat and subsequent
CC heritable transgenerational memory of heat acclimation (global warming)
CC such as early flowering and attenuated immunity; this process includes
CC epigenetic regulation as well as post-transcriptional gene silencing
CC (PTGS) (PubMed:30778176). In response to heat, HSFA2 is activated and
CC promotes the expression of REF6 which in turn derepresses HSFA2, thus
CC establishing an heritable feedback loop able to trigger SGIP1 and
CC subsequent SGIP1-mediated SGS3 degradation; this prevents the
CC biosynthesis of trans-acting siRNA (tasiRNA) and leads to the release
CC of HTT5, which drives early flowering but attenuates immunity
CC (PubMed:30778176). {ECO:0000250|UniProtKB:Q8LFW5,
CC ECO:0000269|PubMed:30778176}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8LFW5}. Nucleus
CC {ECO:0000250|UniProtKB:Q8LFW5}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, leaves, stems,
CC inflorescences and siliques. {ECO:0000269|PubMed:24728648}.
CC -!- INDUCTION: Target of TAS1 (trans-acting siRNA precursor 1)-derived
CC small interfering RNAs in response to temperature variations. Up-
CC regulated by cold (at 4 degrees Celsius) (PubMed:20622450). Highly up-
CC regulated in seedlings exposed to heat shock (PubMed:24728648).
CC {ECO:0000269|PubMed:20622450, ECO:0000269|PubMed:24728648}.
CC -!- SIMILARITY: Belongs to the heat induced plant HTT protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50884.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC025294; AAG50884.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32697.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59870.1; -; Genomic_DNA.
DR EMBL; AY074496; AAL69480.1; -; mRNA.
DR EMBL; BT014865; AAT41848.1; -; mRNA.
DR PIR; E96555; E96555.
DR RefSeq; NP_001322196.1; NM_001333493.1.
DR RefSeq; NP_175578.2; NM_104045.5.
DR AlphaFoldDB; Q8RY97; -.
DR SMR; Q8RY97; -.
DR STRING; 3702.AT1G51670.1; -.
DR PaxDb; Q8RY97; -.
DR PRIDE; Q8RY97; -.
DR EnsemblPlants; AT1G51670.1; AT1G51670.1; AT1G51670.
DR EnsemblPlants; AT1G51670.2; AT1G51670.2; AT1G51670.
DR GeneID; 841592; -.
DR Gramene; AT1G51670.1; AT1G51670.1; AT1G51670.
DR Gramene; AT1G51670.2; AT1G51670.2; AT1G51670.
DR KEGG; ath:AT1G51670; -.
DR Araport; AT1G51670; -.
DR TAIR; locus:2017617; AT1G51670.
DR HOGENOM; CLU_1512647_0_0_1; -.
DR OMA; IPRAEDW; -.
DR OrthoDB; 1455449at2759; -.
DR PhylomeDB; Q8RY97; -.
DR PRO; PR:Q8RY97; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RY97; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0010286; P:heat acclimation; ISS:UniProtKB.
DR GO; GO:0009409; P:response to cold; IEP:UniProtKB.
DR GO; GO:0009408; P:response to heat; IEP:UniProtKB.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..178
FT /note="Protein HEAT-INDUCED TAS1 TARGET 5"
FT /id="PRO_0000439263"
SQ SEQUENCE 178 AA; 19854 MW; A676895A787FAB4E CRC64;
MALPPYDPNF TLAFSYGRRD NVFENDPEHD ESASAAIVAV ELISSARLAL KLDSVRTEYS
AQYLVDKAGS RNLRRRRKLT VKDCLNFALK KGGIPRAEDW PPLGSESKTP SSYEPALVSM
KGEVIEPKDM DEVPELLVHQ SAVGAKLHVF TPHIELQQDA IYLPRQVSMR ATLDLEMG
