HUAL1_ARATH
ID HUAL1_ARATH Reviewed; 1445 AA.
AC Q9LEY4; Q0WN22;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Protein HUA2-LIKE 1 {ECO:0000303|PubMed:25070081};
DE AltName: Full=HUA2-like protein 1 {ECO:0000305};
GN Name=HULK1 {ECO:0000303|PubMed:25070081};
GN OrderedLocusNames=At5g08230 {ECO:0000312|Araport:AT5G08230};
GN ORFNames=T22D6_170;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1317-1445.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=25070081; DOI=10.1111/tpj.12629;
RA Jali S.S., Rosloski S.M., Janakirama P., Steffen J.G., Zhurov V.,
RA Berleth T., Clark R.M., Grbic V.;
RT "A plant-specific HUA2-LIKE (HULK) gene family in Arabidopsis thaliana is
RT essential for development.";
RL Plant J. 80:242-254(2014).
CC -!- FUNCTION: Probable transcription factor that acts with partial
CC redundancy with HULK2 and HULK3. Plays diverse and essential roles in
CC the control of plant development, physiology and flowering time.
CC {ECO:0000269|PubMed:25070081}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25070081}.
CC -!- TISSUE SPECIFICITY: Expressed throughout young primordia, and
CC vegetative and reproductive apices. {ECO:0000269|PubMed:25070081}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but the triple mutant plants hulk1, hulk2 and hulk3 show
CC delayed flowering. {ECO:0000269|PubMed:25070081}.
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DR EMBL; AL357612; CAB93724.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91271.1; -; Genomic_DNA.
DR EMBL; AK229633; BAF01478.1; -; mRNA.
DR PIR; T50508; T50508.
DR RefSeq; NP_196440.1; NM_120906.6.
DR AlphaFoldDB; Q9LEY4; -.
DR SMR; Q9LEY4; -.
DR STRING; 3702.AT5G08230.1; -.
DR iPTMnet; Q9LEY4; -.
DR PaxDb; Q9LEY4; -.
DR PRIDE; Q9LEY4; -.
DR ProteomicsDB; 232121; -.
DR EnsemblPlants; AT5G08230.1; AT5G08230.1; AT5G08230.
DR GeneID; 830719; -.
DR Gramene; AT5G08230.1; AT5G08230.1; AT5G08230.
DR KEGG; ath:AT5G08230; -.
DR Araport; AT5G08230; -.
DR TAIR; locus:2181569; AT5G08230.
DR eggNOG; KOG1904; Eukaryota.
DR HOGENOM; CLU_005040_0_0_1; -.
DR InParanoid; Q9LEY4; -.
DR OMA; QHEYQIS; -.
DR OrthoDB; 143642at2759; -.
DR PhylomeDB; Q9LEY4; -.
DR PRO; PR:Q9LEY4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LEY4; baseline and differential.
DR Genevisible; Q9LEY4; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05834; HDGF_related; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR035496; HDGF-rel_PWWP.
DR InterPro; IPR000313; PWWP_dom.
DR Pfam; PF04818; CID; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SMART; SM00582; RPR; 1.
DR PROSITE; PS51391; CID; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Flowering; mRNA processing; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1445
FT /note="Protein HUA2-LIKE 1"
FT /id="PRO_0000418857"
FT DOMAIN 20..77
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT DOMAIN 838..979
FT /note="CID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00724"
FT REGION 133..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1110..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1174
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1445 AA; 156555 MW; 3969FAF2868AD8FD CRC64;
MAPGRKRGAN KAMAIGEMRL GDLVLAKVKG FPAWPAKIGQ PEDWNQAPDP KKHFVQFYGT
GEIGFVTPPD IQPFTSETKK KLSARCQGKT VKYFSQAVEE ISAAFEESQK QKSDIVGNEA
LLNAVEPSVT KPKYLNQASS DGKSDKFSSR ADPCLGKLVE NNGAEINPDV GEQDSSISNN
RNTSPSSEPV EHGSPDPILK VAVDDKIDNV TCTDHSDGTG NNLVNDQRII RKTTDDSNKR
CKDEVRAKRV PDSRAATDNH ILGPNQKLKG SIKGQDHGSK KGQDHGCRKE SSDSKVVTDL
NIASSKKPKE LLKEKKKRFE NELGKSASGA DESKRAAKRP RSEDAKDQKQ CKSKRLVPVG
EGKAEISDST GVVSIFKREI VLGISALGGK NQFDKDMVAY TKRRKQTVEH TSVSSFPGSL
VKEGANHPEQ KISSSSDSDI KVQAAQLPKR RRAVCIYDDD DDDEDPKTPV HGGLSNIPIA
STDAPKSANA SHNTSIKAKL LAGSTDSVKT GKVPLYKHNK DASLALPDSV EGYNSRMGKP
FKALLQKNIK PILRSPKNSY QLVSFKKQVT GQNKTAKVAG AGMPDSVEGP SNSSYMGKPV
IKLPPQNVKQ TLRSPKKSPQ LFSTKELVAV QNKIAKVSGA GIPKKYHGDS SKDVVAGSDR
VSSSHSQTAN QRSKPAFGEK PTSTPKVATR LDVEVSRDTF VNLSADVIDV NQENGNAPLF
SFGMSDSSSS CMKDLIAAAQ AKRKQAHSQF SPFVNLDHNS LNIDSMQTSK SPFMVQNVSS
PAADATLIVA QEHQEVLTPS NHGRQSSSSN QAGTEENEER RFSSGHRSVG GSLSGATEAA
ISRDTFEGMI ETLSRTKESI RRATRVAIDC AKYGIANEVV ELLIRKLEIE PHFPRKVDLF
FLLDSIIQSS HSQKGRARSL YIPTVQAALP RLLGAAAPPG TGARENRHQC RKVLRLWLKR
KIFPDFLLRR YIGDLGASGD DKTVGFSLRR PSRSERAVDD PLRDMEGMLV DEYGSNANFQ
LPGYLASLTF GDDEEEDLPS TSQEVKNTHM EVKITHMEEP VLALGKLEAH DSSSDKPHCV
VDVNGGLEME DASCQLKDDV CGIEAKEDSP ATTCATELPS FPAGSPPLPH ESPPSPPPQP
PSSPPPPSSP PQLAPAPPPS DHCLPPPTAP LAPAQSIALP PSSITRPSMP SHPSLPLQPG
FAPPAYPLLQ HEYQISMQRD HSSIATSNQI APVPVNAAHG RHADGGVKSE YLMPQSSSFA
PVGMCSYGEP LPFISSKQLE YGNSDVLFKQ EASSQNQQLR PINTSFLQRP MIRNLAPAPS
SHFPLPCRIV QSEPQRSSFP HPYHFPSQPV DGRQHMNEEW RMPPNGCSAD PQYGAWIGVR
NPFPGSRTVT DGVFQPPPER PPSGTVRYQL AANNLQGGST ISGNIASQML LSRPDVPSAA
QYRPS
