HUAL2_ARATH
ID HUAL2_ARATH Reviewed; 1366 AA.
AC F4IN78; Q8GYT7;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2012, sequence version 2.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Protein HUA2-LIKE 2 {ECO:0000303|PubMed:25070081};
DE AltName: Full=HUA2-like protein 2 {ECO:0000305};
GN Name=HULK2 {ECO:0000303|PubMed:25070081};
GN OrderedLocusNames=At2g48160 {ECO:0000312|Araport:AT2G48160};
GN ORFNames=F11L15.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=25070081; DOI=10.1111/tpj.12629;
RA Jali S.S., Rosloski S.M., Janakirama P., Steffen J.G., Zhurov V.,
RA Berleth T., Clark R.M., Grbic V.;
RT "A plant-specific HUA2-LIKE (HULK) gene family in Arabidopsis thaliana is
RT essential for development.";
RL Plant J. 80:242-254(2014).
CC -!- FUNCTION: Probable transcription factor that acts with partial
CC redundancy with HULK1 and HULK3. Plays diverse and essential roles in
CC the control of plant development, physiology and flowering time.
CC {ECO:0000269|PubMed:25070081}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25070081}.
CC -!- TISSUE SPECIFICITY: Expressed throughout young primordia, and
CC vegetative and reproductive apices. {ECO:0000269|PubMed:25070081}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but the triple mutant plants hulk1, hulk2 and hulk3 show
CC delayed flowering. {ECO:0000269|PubMed:25070081}.
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DR EMBL; AC006072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; AEC10947.1; -; Genomic_DNA.
DR EMBL; AK117393; BAC42062.1; -; mRNA.
DR PIR; B84924; B84924.
DR RefSeq; NP_850485.2; NM_180154.7.
DR AlphaFoldDB; F4IN78; -.
DR SMR; F4IN78; -.
DR STRING; 3702.AT2G48160.1; -.
DR PaxDb; F4IN78; -.
DR PRIDE; F4IN78; -.
DR ProteomicsDB; 230158; -.
DR GeneID; 819428; -.
DR KEGG; ath:AT2G48160; -.
DR Araport; AT2G48160; -.
DR TAIR; locus:2039351; AT2G48160.
DR eggNOG; KOG1904; Eukaryota.
DR HOGENOM; CLU_004888_0_0_1; -.
DR InParanoid; F4IN78; -.
DR PhylomeDB; F4IN78; -.
DR PRO; PR:F4IN78; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IN78; baseline and differential.
DR Genevisible; F4IN78; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05834; HDGF_related; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR035496; HDGF-rel_PWWP.
DR InterPro; IPR000313; PWWP_dom.
DR Pfam; PF04818; CID; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SMART; SM00582; RPR; 1.
DR PROSITE; PS51391; CID; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Flowering; mRNA processing; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1366
FT /note="Protein HUA2-LIKE 2"
FT /id="PRO_0000418859"
FT DOMAIN 24..81
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT DOMAIN 836..977
FT /note="CID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00724"
FT REGION 111..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1155
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1247
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 11
FT /note="K -> R (in Ref. 2; AEC10947)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1366 AA; 149639 MW; 625CBF34F7D11285 CRC64;
MAPSRRKGGG KAAAVAAACR KRKVGDLVLA KVKGFPAWPA VVSEPEKWDA SPDSKKVFVH
FFGTQQIAFC NPGDVEAFTE ERKQSLLTRR HAKGSDFVRA VKEIIESYEK LKQQERASDP
KSAEEGTLGS AENTTLMPQV IEIPTATSLT QMNSDPSHGR DESTLLNEDA SAAEQMLALR
DNSGPRNKAC DSAVVKEPRK IATYSSRKRN GGVRSQNCAP QNETCPVQRS KSPSRLQTEK
LQSSMLQNSD GGQTIDDVED GALRREKRIR RSSGHSESDD VATSSLNSHG SDEENASEIA
TVESDNNRNE GNGVDSGSKV EQIDIGGKFL EGDYDLNKGL NFQINIMVKR KKRKPTRKRG
TSDVVDPQAK VEGEAVPEAG ARNNVQTSQN SHEKFTERPC EENGDEHLPL VKRARVRMSR
AFYGNHEANS SLQAEERSPK DTVVSATAQT SPSDIISSHD TFAVEESKFF EVSAKLSGDM
VNVAPSPVEK SHDGMSPSEA CVQTVREREY AMGWNELSKT PDDKSAGPQY NQVSSLPAGE
AQTASVPEAV CPEVLKLLTS ESDLPAVQYC QVAKIEPSMD PNTVDSSANN ASEICSLSIP
SQLSGQDRSN DQDACVSLEN SREYLNEEGS KIDACVAQVV QSEAIEHSPS SCLVVNKQET
ENMPKTVNML LKEGHGSLGE ECAIVEPAQC TPNLPISATE SDVIVGENVP LNEIGCTKCE
DAVEDSRQLK MIGETNDQKQ QVQTNNSVLV SENLSREKMS FSPAITADTP ARGTPHSSSV
YYHISTSESA NDMQNNSSGS PNIPTGEKKN DCDAIVKEEE KIETGVCQGQ KVVSCDVQST
RESYEDALCS LVRTKESIGR ATCLAMDLMK FGVSAKAMEI LAHTLESESN LKRRVDLFFL
VDSIAQCSKG LKGDTGCVYL SAIQVILPRL LAAAVPAGAT TQENRKQCLK VLKLWLERRI
LPESIVRHHI RELDSHSIVP ACLYSRRSAR TERSLDDPVR DMEDMLVDEY GSNSTLQLPG
FCMPALLKDE EGGSDSEGGC DSEGGSDSDG GDFESVTPEH ESRILEENVS SSTAERHTLI
LEDVDGELEM EDVAPPWGTE NCTHTDQADN TKVSNCQLGQ QHRPVFGTSH QHMSLSSPPL
PSSSPPPPPA PPSQQGECAM PDSYLNGFEN GGYRNVHGDQ QAGPLRMNPP LSGSTMHYQG
PESSYISGVQ LTNSIPQADG SNFQHRPYPS HPHPHPPPPP PPPQHQFSFR EPGHVLKSHR
DAPSYSHRSH YVPNCDERNF HDNHERMRHA PFENRDNWRY PPSSSYGSRY QDEHKAPYPS
SSYNGVRWDN PPRQYNNRPS FHPKPHSEGP APVGMRDPGM WHQRSD
