HUAL3_ARATH
ID HUAL3_ARATH Reviewed; 1347 AA.
AC F4IZM8; Q9LYB5;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Protein HUA2-LIKE 3 {ECO:0000303|PubMed:25070081};
DE AltName: Full=HUA2-like protein 3 {ECO:0000305};
GN Name=HULK3 {ECO:0000303|PubMed:25070081};
GN OrderedLocusNames=At3g63070 {ECO:0000312|Araport:AT3G63070};
GN ORFNames=T20O10_170;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=25070081; DOI=10.1111/tpj.12629;
RA Jali S.S., Rosloski S.M., Janakirama P., Steffen J.G., Zhurov V.,
RA Berleth T., Clark R.M., Grbic V.;
RT "A plant-specific HUA2-LIKE (HULK) gene family in Arabidopsis thaliana is
RT essential for development.";
RL Plant J. 80:242-254(2014).
CC -!- FUNCTION: Probable transcription factor that acts with partial
CC redundancy with HULK1 and HULK2. Plays diverse and essential roles in
CC the control of plant development, physiology and flowering time.
CC {ECO:0000269|PubMed:25070081}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25070081}.
CC -!- TISSUE SPECIFICITY: Expressed throughout young primordia, and
CC vegetative and reproductive apices. {ECO:0000269|PubMed:25070081}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but the triple mutant plants hulk1, hulk2 and hulk3 show
CC delayed flowering. {ECO:0000269|PubMed:25070081}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB87752.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL163816; CAB87752.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE80431.1; -; Genomic_DNA.
DR PIR; T48096; T48096.
DR RefSeq; NP_191866.3; NM_116172.3.
DR AlphaFoldDB; F4IZM8; -.
DR SMR; F4IZM8; -.
DR STRING; 3702.AT3G63070.1; -.
DR iPTMnet; F4IZM8; -.
DR PaxDb; F4IZM8; -.
DR PRIDE; F4IZM8; -.
DR ProteomicsDB; 232177; -.
DR EnsemblPlants; AT3G63070.1; AT3G63070.1; AT3G63070.
DR GeneID; 825482; -.
DR Gramene; AT3G63070.1; AT3G63070.1; AT3G63070.
DR KEGG; ath:AT3G63070; -.
DR Araport; AT3G63070; -.
DR TAIR; locus:2099242; AT3G63070.
DR eggNOG; KOG1904; Eukaryota.
DR HOGENOM; CLU_004888_0_0_1; -.
DR InParanoid; F4IZM8; -.
DR OMA; NDNIHSR; -.
DR OrthoDB; 93330at2759; -.
DR PRO; PR:F4IZM8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4IZM8; baseline and differential.
DR Genevisible; F4IZM8; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05834; HDGF_related; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR035496; HDGF-rel_PWWP.
DR InterPro; IPR000313; PWWP_dom.
DR Pfam; PF04818; CID; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SMART; SM00582; RPR; 1.
DR PROSITE; PS51391; CID; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Flowering; mRNA processing; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1347
FT /note="Protein HUA2-LIKE 3"
FT /id="PRO_0000418858"
FT DOMAIN 24..81
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT DOMAIN 845..986
FT /note="CID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00724"
FT REGION 110..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1220
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1347 AA; 149318 MW; 3328522432A8C87A CRC64;
MAPSRKRGGG RAAAASSARR EWKVGDLVLA KVKGFPAWPA VVDEPEKWGH SADSKKVTVH
FFGTQQIAFC NHGDVESFTE EKKQSLLTRR HAKGSDFVRA VKEITESYEK LKQQDQASGP
KYAEETTAGS SGNTSQLPQA CENLIGSRLD TQIESSSSHG RDELTLLSED ASAAEQMLAL
RHNTLAHNGA CDSAAAKDLC EIATYSSRRR NERVRALKYA PQSIILPVEH SKISSRLELD
RVQRSMLQCS DGGPSVNSIN GKAIRRRKRI RTSGQSESDD VVSSDLNLHG SDEDNASEIA
TVESNNNSRN EGNGVDSGSK VEYSDAVGEG CDGGHELNKG LDFHISTMVK RKKRKPTRKR
ETSDIIDPPA KVEAEGLGPN ACDSCQRSQN SHERLNERPC EENGDEHLPL VKRARVRMSR
AFYADEKVNA SSQVEERSSK DTLLSAALQT SPSVNHENGI GSGHDTSAAE EFNSFELSAK
LSGVMVDVVP SHMEKPSDRM SPSVACVQTV GDRQTAVNFH ENEFTMTLDD EVTRAQSNQL
SSLVETEARV PEVVQGCSEE SQTGNCLISE TDPIDIQCSH QSEKHETPLN PDIVDSSANK
SPGLCSSLDM TTTVVPAQSP HQHKIQEYDS SDHSLVIVGD SLNGKCEKID YCMTQVVQSQ
ALEPPPPLFC SVVNYQEVEN LQETENTLWK ENQGSPGKEL DSDKQAHMIQ NPVLSATESE
MIVDDAEPQY ETVYSHCADA VENRELEKSC EVDEQKEQMQ ATNSISVSEN FSREKLNSSP
ARGTPNCNSV CRISTAESEN AMQNNSYYST NVQYGENKSL NVDTVKEESK VETGTTQVKK
VVSSDVQCTV ESFETALDSL VRTKETIGRA TRLAMDLAKF GVSAKAMEIL AHTLESESNL
QRRVDLFFLV DSIAQCSKGL NGDAGGVYLS SIQAMLPRLL TAAVPAGATT QENRKQCLKV
LRLWLERRIL PESIVRHHIR ELDSLSNVPA CLYSRRSART ERALDDPVRD MEGILVDEYG
SNSTLQLHGF CIPPILRDED EGSDSDGGDF ESVTPEHESR SLEEHVTPSI TERHTRILED
VDGELEMEDV APPWEGGSSA SAITDQADNR ESANCLLVPG TSHQNVTSSS PPARPSQNAQ
LAMSNSYSNG FDYRRNPSMQ GDYHAGPPRM NPPMHYGSPE PSYSSRVSLS KSMPRGEGSN
FQHRPYPSSH PPPPPPSHHY SYMEPDHHIK SRREGLSYPH RSHYTLEFDE RNYQDSYERM
RPEPCENRDN WRYHPPSSHG PRYHDRHKGP HQSSSYSGHH RDSGRLQNNR WSDSPRAYNN
RHSYHYKQHS EGPVPVGMRD PGTWHQR
