ID   HUM6_CAEBR              Reviewed;        2099 AA.
AC   Q622K8; A8WS20;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Unconventional myosin heavy chain 6;
GN   Name=hum-6 {ECO:0000250|UniProtKB:P91443}; ORFNames=CBG02140;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity.
CC       Unconventional myosins serve in intracellular movements. Their highly
CC       divergent tails are presumed to bind to membranous compartments, which
CC       would be moved relative to actin filaments (By similarity).
CC       {ECO:0000250|UniProtKB:P97479}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P91443}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000305}.
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DR   EMBL; HE601451; CAP23278.3; -; Genomic_DNA.
DR   RefSeq; XP_002643889.1; XM_002643843.1.
DR   AlphaFoldDB; Q622K8; -.
DR   SMR; Q622K8; -.
DR   STRING; 6238.CBG02140; -.
DR   EnsemblMetazoa; CBG02140.1; CBG02140.1; WBGene00025248.
DR   GeneID; 8585882; -.
DR   KEGG; cbr:CBG_02140; -.
DR   CTD; 8585882; -.
DR   WormBase; CBG02140; CBP06188; WBGene00025248; Cbr-hum-6.
DR   eggNOG; KOG4229; Eukaryota.
DR   HOGENOM; CLU_000192_14_1_1; -.
DR   InParanoid; Q622K8; -.
DR   OMA; LHRGNKH; -.
DR   OrthoDB; 527681at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005902; C:microvillus; IBA:GO_Central.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0007423; P:sensory organ development; IBA:GO_Central.
DR   GO; GO:0007605; P:sensory perception of sound; IBA:GO_Central.
DR   GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR   CDD; cd14473; FERM_B-lobe; 2.
DR   CDD; cd13198; FERM_C1_MyoVII; 1.
DR   CDD; cd13199; FERM_C2_MyoVII; 1.
DR   CDD; cd01381; MYSc_Myo7; 1.
DR   Gene3D; 1.20.80.10; -; 2.
DR   Gene3D; 1.25.40.530; -; 3.
DR   Gene3D; 2.30.29.30; -; 2.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR041793; MyoVII_FERM_C1.
DR   InterPro; IPR041794; MyoVII_FERM_C2.
DR   InterPro; IPR036106; MYSc_Myo7.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF00784; MyTH4; 2.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00295; B41; 2.
DR   SMART; SM00015; IQ; 3.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00139; MyTH4; 2.
DR   SUPFAM; SSF47031; SSF47031; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54236; SSF54236; 2.
DR   PROSITE; PS50057; FERM_3; 2.
DR   PROSITE; PS50096; IQ; 3.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51016; MYTH4; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Actin-binding; ATP-binding; Coiled coil; Cytoplasm; Motor protein; Myosin;
KW   Nucleotide-binding; Reference proteome; Repeat; SH3 domain.
FT   CHAIN           1..2099
FT                   /note="Unconventional myosin heavy chain 6"
FT                   /id="PRO_0000306246"
FT   DOMAIN          62..732
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT   DOMAIN          735..757
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116,
FT                   ECO:0000305"
FT   DOMAIN          758..787
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          804..833
FT                   /note="IQ 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          930..1169
FT                   /note="MyTH4 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00359"
FT   DOMAIN          1172..1212
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1174..1485
FT                   /note="FERM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   DOMAIN          1480..1548
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          1625..1773
FT                   /note="MyTH4 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00359"
FT   DOMAIN          1779..2087
FT                   /note="FERM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          609..631
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P08799"
FT   REGION          711..725
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P08799"
FT   REGION          826..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          861..899
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          788..2099
FT                   /evidence="ECO:0000255"
FT   BINDING         155..162
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P08799"
SQ   SEQUENCE   2099 AA;  239594 MW;  DF58C4D38057267F CRC64;
     MVLVSKGDFI WIEPGKAEGS IPIGARVIDQ DHGRLKVIDD LGNEQWLSAD RRVRLMHPTS
     VQGVEDMCQL GDFHESAILR NLFIRYREKL IYAYTGSILI AVNPYMDIAI YTADEIRMYK
     RKRIGELPPH IFAIADNAYT NMRREKKNQS VIISGESGAG KTESTKLVLQ FLATISGQHS
     WIEQQVLEAN PVLEAFGNAK TIRNDNSSRF GKYIDVHFNE SGSIEGAKIE QYLLEKSRIV
     TQSENERNYH IFYCLLAGLS KEEKMELELG TAADYYYLIQ GKTLTAEGRD DAADLAEIRS
     AMRVLMINEQ EIGSIFKLLA ALLHIGNIRF RQNTTDNMES VDVADPSTLV RIAKLLNLHE
     QNLLDAITTK SLVTREERVI SRLNGQQAID ARDALAKAIY GKLFIHIVRR VNDAIYKPSQ
     SIRTSIGILD IFGFENFESN SFEQLCINFA NETLQQFFVQ HVFKMEQKEY DEENINWRHI
     KFVDNQATVD LIAQRPMNIL SLIDEESIFP KGTDKTMLLK LHSTHGRNEL YLQPKSELQR
     AFGVTHFAGS VFYNTRGFLE KNRDSFSGDL SALISSSKMP FLARLFDDLE YDTSSRKKVT
     VGNQFRRSLE QLMTQLTQTH PFFIRCIKPN ELKRALVMDR DLVLRQLRYS GMMETIKIRR
     SGYPIRHDYY PFVFRYRVLV SSIRGPANRI DLHDAAKKIC HKVLGPNADY QLGKTKVFLK
     DKHDLVLEQE YYRILKDKAV IIQKNVRRWL VRKDFEKQRQ AAVTIQTAWR GYDQRKRYRQ
     IISGFSRLQA VLRSRQLVSH YQSLRKTIIQ FQAVCRGTLL RRQVGEMRRR GEKAPLTEVS
     STASVISDSH EEELVSHLFD FLPSDGKDSG NENDSTDSSR RGSYSRLHPS PVMPPTNIPR
     VDSFIDEDLS KFQFGKYAAT FFQAQATATH IKKPIKTALL THTEPSAQLA ALASWTTILR
     FMGDLSDVKP GSTNGSEIYD KTPVMSRLYA TLGKKFSTRD VEEALLSSEY GGNKTLKKGM
     GKKLISMTLK RKGKIGGSDT SSISSDSAYS GFNAMLENKP MTSLDKLHYI IGLGILREDL
     RDEIYCQLCK QLSNNPSKLS AARGWILLSL CVGCFAPSER FIKYLFCFIR ERGPAGTGYS
     TYIEDRLRRT QVNGTRHQPP SYVELQANKS QKPVVLAVTF MDGSVKTLCA DSATTASELC
     KQLAEKVGLT NSFGFSLYIA LFDKVSSLGS GTDHVMDAIS QCEQYAKEQG RQERNAPWRL
     FFRKEIFSPW HDPKDDAVST NLIYQQVIRG IKYGEYRCDK DEELAAICAQ QYYIDEGTMD
     VNKLENNLAS YLPDFEMAGK DMALEKWTQT IMHQYRKKFT GRLPSQIEVK EDVVSIAKTK
     WPLLFSRFYE ALKFAGPPLP KNEVIIAVNW TGVYVVDDRE HVMLEFSFPE ISTAYYGKGK
     RSTTDTCTIR SVVGDEYTFQ SPNADDITNL IVLFLEGLKK RSRYLVAIKA QKGDEKNNFL
     DFEKGDLLIL VNEFTGNTLL TESVVKGENS RTCLFGLIRA ENVYVLPTLV KPSKNTLQIF
     PKDMDMSLDL FNNNKQVTVI DYNAEPYTLE NFAEDNFNSQ VKRVGSQISL MTLRKKESQI
     ESWRFSRDHI EHPLLKKLNG RDDACRGAVE IFAAIMKYMG DEPSKRSRLG THLTDHIFKL
     PISMEALRDE LYCQLVKQLT LNPSIMSEEK GWELLWMATG LFAPSAALAK EISHFLKSRP
     HPIALDCQNR MQKLAKGGSR KYPPHLVEVE AIQHKTTQIF HKVFFPDKTD EAIEVDSATR
     ARDFCHKIGY RLGLKSSDGF SLFVKIKDKV LAVPETEFFF DYVRSLSDWV HTNHAMQKDS
     TMIPINYQVY FMRKLWFNFV PGADSQADII FHYHQESQKY LLGYHKTTKN DVIELAALIL
     RAMTKEGKNA PLAQIPQLLD DIVPKDSLKM CSASEWRKTI SNAYARVEHL KPDQAKIEFL
     KYICRWPTFG SAFFPVSQYS DLSLPDRLLL AINQTGVNIY HLESKNLLVQ YPFNVICNWT
     SGNTYFNMTV GNMLKGNEGK KLLLDTTVGY KMDDLLTSYI SLLISNQTNQ PSKHREVAL