ID   HUNB_APIME              Reviewed;          69 AA.
AC   P31504;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein hunchback;
DE   Flags: Fragment;
GN   Name=hb;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1438276; DOI=10.1073/pnas.89.22.10782;
RA   Sommer R.J., Retzlaff M., Goerlich K., Sander K., Tautz D.;
RT   "Evolutionary conservation pattern of zinc-finger domains of Drosophila
RT   segmentation genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:10782-10786(1992).
CC   -!- FUNCTION: Gap class segmentation protein that controls development of
CC       head structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the hunchback C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; L01587; AAA27734.1; -; Genomic_DNA.
DR   AlphaFoldDB; P31504; -.
DR   SMR; P31504; -.
DR   STRING; 7460.GB50986-PA; -.
DR   PaxDb; P31504; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; P31504; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0040034; P:regulation of development, heterochronic; IEA:InterPro.
DR   GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR   InterPro; IPR027742; Hunchback.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24392:SF33; PTHR24392:SF33; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           <1..>69
FT                   /note="Protein hunchback"
FT                   /id="PRO_0000046968"
FT   ZN_FING         <1..11
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         17..39
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         45..69
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   NON_TER         1
FT   NON_TER         69
SQ   SEQUENCE   69 AA;  8291 MW;  61F7F5685261B3D4 CRC64;
     KHHLEYHLRN HFGSKPFKCE KCSYSCVNKS MLNSHLKSHS NVYQYRCANC TYATKYCHSL
     KLHLRKYSH