ID   HUNB_BOMMO              Reviewed;         385 AA.
AC   O18326;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Protein hunchback;
DE   Flags: Fragment;
GN   Name=hb;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Kinshu X Showa;
RX   PubMed=9352206; DOI=10.1046/j.1440-169x.1997.t01-3-00013.x;
RA   Xu X., Xu P., Amanai K., Suzuki Y.;
RT   "Double-segment defining role of even-skipped homologs along the evolution
RT   of insect pattern formation.";
RL   Dev. Growth Differ. 39:515-522(1997).
CC   -!- FUNCTION: Gap class segmentation protein that controls development of
CC       head structures. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the hunchback C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; D38487; BAA22892.1; -; mRNA.
DR   AlphaFoldDB; O18326; -.
DR   STRING; 7091.BGIBMGA003334-TA; -.
DR   PRIDE; O18326; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; O18326; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0040034; P:regulation of development, heterochronic; IEA:InterPro.
DR   GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR   InterPro; IPR027742; Hunchback.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24392:SF33; PTHR24392:SF33; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           <1..>385
FT                   /note="Protein hunchback"
FT                   /id="PRO_0000046970"
FT   ZN_FING         229..251
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         258..280
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         286..308
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         314..338
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         385
SQ   SEQUENCE   385 AA;  42749 MW;  950F28A0A9809E92 CRC64;
     IGGIPAANAK CASHAGMTPA PHSSHPQAWG PLLQPPTVKT EPMDDGNFSK EQTSGFYSEG
     FHSASPSSSS KDSNGHSPRS SGSTREPSPF YDAMPLKAKA NLGMHLDSFR NSLPYSLLTP
     PGFESRASDA RDHSPSYESY SPRTLAPPAH VSHPLGRSDA TPPKSPPRTP SSPERRSFDR
     FHDSGFDGVD HNKHDGDDGR EGSGLEDDFD EEPGLRVPAV NSHGKVKTFK CKQCEFVAVT
     KLSFWEHSKE HIKPEKMLCC RKCPFVTEYK HHLEYHMRNH MGSKPFQCSQ CSYSCVNKSM
     LNSHLKSHSN VYQYRCADCN YATKYCDSLK LHLRKYQHNP AMVLNLDGTP NPLPIIDVYG
     TRRGPKQKPL SKIFEQQTGT NNHSP