ID   HUNB_CLOAL              Reviewed;         485 AA.
AC   O96785;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Protein hunchback;
DE   Flags: Fragment;
GN   Name=hb;
OS   Clogmia albipunctata (Mothmidge).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Clogmia.
OX   NCBI_TaxID=85120;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10079357; DOI=10.1007/s004270050238;
RA   Rohr K.B., Tautz D., Sander K.;
RT   "Segmentation gene expression in the mothmidge Clogmia albipunctata
RT   (Diptera, psychodidae) and other primitive dipterans.";
RL   Dev. Genes Evol. 209:145-154(1999).
CC   -!- FUNCTION: Gap class segmentation protein that controls development of
CC       head structures. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the hunchback C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AJ131041; CAA10281.1; -; mRNA.
DR   AlphaFoldDB; O96785; -.
DR   SMR; O96785; -.
DR   PRIDE; O96785; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0040034; P:regulation of development, heterochronic; IEA:InterPro.
DR   GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR   InterPro; IPR027742; Hunchback.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24392:SF33; PTHR24392:SF33; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW   Repeat; Zinc; Zinc-finger.
FT   CHAIN           <1..485
FT                   /note="Protein hunchback"
FT                   /id="PRO_0000046972"
FT   ZN_FING         87..109
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         116..138
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         144..166
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         172..196
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         432..454
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         460..484
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..70
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   485 AA;  55367 MW;  8BEAC3B3C3B0C37C CRC64;
     TSSTARKTPE KDSLKQDQNQ LLKTPIQTNG NQQSTFDSGE DSHSMPDSDL LEPVITDGAD
     VDDENDAEED DDIRTPKINS HGKMKTYKCK QCDFIAVTKL SFWEHNRIHI KPEKMLKCQK
     CPFITEYKHH LEYHLRNHNG SKPFQCKQCN YSCVNKSMLN SHMKSHSNIY QYRCKDCNYA
     TKYCHSLKLH LRKYSHNPPM VLNYDGTPNP LRIIDVYGTR RGPKVKFHKD EGGHNLLNSN
     INTSRRSKSG KRDSFPNFEQ SQHVPTPPSS QALAMLPNLA NIFQQSPSMP LFPYLNLNFH
     HILAQQKAAL SQISPSINGW QNEENCNEEE TPEKEEDPKR MSALDLSSNP STPSTVSQVK
     HKRKGRAFKL ELMKESSDDD EGQTIRTLGE IRSELETPKP VQLQLPTSST TTPLKTTSED
     DSTSVEPLQN LYECKFCDIS FKHAVLYTIH MGYHGYNDVF KCNACGKKCE DRVAFFLHIA
     RDAHA