ID   HUNB_DROSE              Reviewed;         757 AA.
AC   O62538;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Protein hunchback;
GN   Name=hb;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12572604; DOI=10.1093/oxfordjournals.molbev.a025868;
RA   Tautz D., Nigro L.;
RT   "Microevolutionary divergence pattern of the segmentation gene hunchback in
RT   Drosophila.";
RL   Mol. Biol. Evol. 15:1403-1411(1998).
CC   -!- FUNCTION: Gap class segmentation protein that controls development of
CC       head structures. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hunchback C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AJ005374; CAA06504.1; -; Genomic_DNA.
DR   AlphaFoldDB; O62538; -.
DR   PRIDE; O62538; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR   GO; GO:0007400; P:neuroblast fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR   GO; GO:0040034; P:regulation of development, heterochronic; IEA:InterPro.
DR   GO; GO:2000177; P:regulation of neural precursor cell proliferation; IEA:EnsemblMetazoa.
DR   GO; GO:0050767; P:regulation of neurogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR   InterPro; IPR027742; Hunchback.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24392:SF33; PTHR24392:SF33; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW   Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..757
FT                   /note="Protein hunchback"
FT                   /id="PRO_0000046961"
FT   ZN_FING         239..261
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         268..290
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         296..318
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         324..348
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         704..726
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         732..756
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          30..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          511..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        602..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..692
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  83175 MW;  318404E80D295B0E CRC64;
     MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP STNHLEQFLK
     QQQQHQQQPM DTLCAMTPSP SQNDQNSLQH YDANLQQQLL QQQQYQQHFQ AAQQQHHHHH
     HLMGGFNPLT PPGLPNPMQH FYGGNLRPSP QPTPTSASTI APVAVATGSS EKLQALTPPM
     DVTPPKSPAK SSQSNIEPEK EHDQMSNSSE DMKYMAESED DDTNIRMPIY NSHGKMKNYK
     CKTCGVVAIT KVDFWAHTRT HMKPDKILQC PKCPFVTEFK HHLEYHIRKH KNQKPFQCDK
     CSYTCVNKSM LNSHRKSHSS VYQYRCADCD YATKYCHSFK LHLRKYGHKP GMVLDEDGTP
     NPSLVIDVYG TRRGPKSKNG GPIASGGSGS GSRKSNVAAV APQQQQSQPA QPVATSHLSA
     ALQGFPLVQS NSAPPAASPV LPLPASPAKS VASVEQTPSL PSPANLLPPL ASLLQQNRNM
     AFFPYWNLNL QMLAAQQQAA VLAQLSPRMR EQLQQQNQQQ SDNEEEDQDD EYERKSVDSA
     MDLSQGTPVK EDEQQQQPQQ PLAMNLKVEE EATPLMSSSN ASRRKGRVLK LDTLLQLRSE
     AMTSPEQLKV PSTPMPTASS PIAGRKPMPE EHCSGTSSAD ESMERPHVRQ ANTSASSTAS
     SSGNSSNASS NSNGNSSSNS SSNGTTSAVA APPSGTPAAA GAIYECKYCD IFFKDAVLYT
     IHMGYHSCDD VFKCNMCGEK CDGPVGLFVH MARNAHS