HUNB_DROYA
ID HUNB_DROYA Reviewed; 759 AA.
AC O62541; B4PT90;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein hunchback {ECO:0000250|UniProtKB:P05084};
GN Name=hb {ECO:0000250|UniProtKB:P05084};
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12572604; DOI=10.1093/oxfordjournals.molbev.a025868;
RA Tautz D., Nigro L.;
RT "Microevolutionary divergence pattern of the segmentation gene hunchback in
RT Drosophila.";
RL Mol. Biol. Evol. 15:1403-1411(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Gap class segmentation protein that controls development of
CC head structures. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the hunchback C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AJ005376; CAA06506.1; -; Genomic_DNA.
DR EMBL; CM000160; EDW96551.1; -; Genomic_DNA.
DR RefSeq; XP_002096839.1; XM_002096803.2.
DR AlphaFoldDB; O62541; -.
DR SMR; O62541; -.
DR STRING; 7245.FBpp0269844; -.
DR EnsemblMetazoa; FBtr0271352; FBpp0269844; FBgn0022824.
DR GeneID; 6536253; -.
DR KEGG; dya:Dyak_GE24834; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_021336_0_0_1; -.
DR OMA; QNSLQHF; -.
DR OrthoDB; 1318335at2759; -.
DR Proteomes; UP000002282; Chromosome 3R.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0009948; P:anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0007400; P:neuroblast fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0040034; P:regulation of development, heterochronic; IEA:InterPro.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0050767; P:regulation of neurogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR InterPro; IPR027742; Hunchback.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24392:SF33; PTHR24392:SF33; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW Phosphoprotein; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..759
FT /note="Protein hunchback"
FT /id="PRO_0000046966"
FT ZN_FING 241..263
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..350
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 706..728
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 734..758
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 30..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 179
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P05084"
FT MOD_RES 189
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05084"
FT MOD_RES 208
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05084"
FT MOD_RES 210
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05084"
FT MOD_RES 211
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05084"
FT MOD_RES 537
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05084"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05084"
FT CONFLICT 495
FT /note="A -> L (in Ref. 1; CAA06506)"
FT /evidence="ECO:0000305"
FT CONFLICT 520
FT /note="Q -> H (in Ref. 1; CAA06506)"
FT /evidence="ECO:0000305"
FT CONFLICT 653
FT /note="P -> A (in Ref. 1; CAA06506)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 759 AA; 83262 MW; 1C9920F0C8F29985 CRC64;
MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP STNHLEQFLK
QQQQQQHQQQ PMDTLCAMTP SPSQNDQNSL QHYDASLQQQ LLQQQQYQQH FQAAQQQHHH
HHHLMGGFNP LTPPGLPNPM QHFYGGNLRP SPQPTPTSAS TVAPVAVATG SSEKLQALTP
PMDVTPPKSP AKSSQSNIEP EKEHDQMSNS SEDMKYMAES EDDDTNIRMP IYNSHGKMKN
YKCKTCGVVA ITKVDFWAHT RTHMKPDKIL QCPKCPFVTE FKHHLEYHIR KHKNQKPFQC
DKCSYTCVNK SMLNSHRKSH SSVYQYRCAD CDYATKYCHS FKLHLRKYGH KPGMVLDEDG
TPNPSLVIDV YGTRRGPKSK NGGPIASGGS GSGSRKPNVA AVAPQQQQSQ PAQPATSQLS
AALQGFPLVQ SNSAPPAASP VLPLPASPAK SVASVEQTPS LPSPANLLPP LASLLQQNRN
MAFFPYWNLN LQMLAAQQQA AVLAQLSPRM REQLQQQNQQ QSDNEEEEQD DEYERKSVDS
AMDLSQGTPV KEDDQHQQQQ QPQQPLAMNL KVEEEATPLM SSSNASRRKG RVLKLDTLLQ
LRSEAMTSPE QLKVPSTPMP TASSPIAGRK PMPEDHCSGT SSADESMETA HVPQANTSAS
STASSSGNSS NASSNGNSSS NSSSNGTSSA AAAPASGTPA AAGAIYECKY CDIFFKDAVL
YTIHMGYHSC DDVFKCNMCG EKCDGPVGLF VHMARNAHS
