HUP1_PARKE
ID HUP1_PARKE Reviewed; 534 AA.
AC P15686; Q39523;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=H(+)/hexose cotransporter 1;
GN Name=HUP1;
OS Parachlorella kessleri (Green alga) (Chlorella kessleri).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Parachlorella.
OX NCBI_TaxID=3074;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2599110; DOI=10.1016/0014-5793(89)81489-9;
RA Sauer N., Tanner W.;
RT "The hexose carrier from Chlorella. cDNA cloning of a eucaryotic H+-
RT cotransporter.";
RL FEBS Lett. 259:43-46(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1868571; DOI=10.1007/bf00336489;
RA Wolf K., Tanner W., Sauer N.;
RT "The Chlorella H+/hexose cotransporter gene.";
RL Curr. Genet. 19:215-219(1991).
CC -!- FUNCTION: Active uptake of hexoses.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- INDUCTION: By glucose.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; Y07520; CAA68813.1; -; mRNA.
DR EMBL; X55349; CAA39036.1; -; Genomic_DNA.
DR PIR; S14144; S14144.
DR AlphaFoldDB; P15686; -.
DR SMR; P15686; -.
DR TCDB; 2.A.1.1.14; the major facilitator superfamily (mfs).
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Sugar transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..534
FT /note="H(+)/hexose cotransporter 1"
FT /id="PRO_0000050428"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..144
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..299
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..328
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 350..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 374..387
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 409..433
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 455..456
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 478..534
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 60
FT /note="Missing (in Ref. 1; CAA68813)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="P -> L (in Ref. 1; CAA68813)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="C -> R (in Ref. 1; CAA68813)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 534 AA; 57523 MW; 3B238E8710AA2237 CRC64;
MAGGGVVVVS GRGLSTGDYR GGLTVYVVMV AFMAACGGLL LGYDNGVTGG VVSLEAFEKK
FFPDVWAKKQ EVHEDSPYCT YDNAKLQLFV SSLFLAGLVS CLFASWITRN WGRKVTMGIG
GAFFVAGGLV NAFAQDMAML IVGRVLLGFG VGLGSQVVPQ YLSEVAPFSH RGMLNIGYQL
FVTIGILIAG LVNYAVRDWE NGWRLSLGPA AAPGAILFLG SLVLPESPNF LVEKGKTEKG
REVLQKLCGT SEVDAEFADI VAAVEIARPI TMRQSWASLF TRRYMPQLLT SFVIQFFQQF
TGINAIIFYV PVLFSSLGSA NSAALLNTVV VGAVNVGSTL IAVMFSDKFG RRFLLIEGGI
QCCLAMLTTG VVLAIEFAKY GTDPLPKAVA SGILAVICIF ISGFAWSWGP MGWLIPSEIF
TLETRPAGTA VAVVGNFLFS FVIGQAFVSM LCAMEYGVFL FFAGWLVIMV LCAIFLLPET
KGVPIERVQA LYARHWFWNR VMGPAAAEVI AEDEKRVAAA SAIIKEEELS KAMK
